Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation

Autor(es)

Van Campenhout, Raf ^[1] ; Yanguas, Sara Crespo ^[1] ; Cooreman, Axelle ^[1] ; Gijbels, Eva ^[1] ; Leroy, Kaat ^[1] ; Vilas-Boas, Vania ^[1] ; Devoogdt, Nick ^[2] ; Muyldermans, Serge ^[3] ; Cogliati, Bruno ^[4] ; Vinken, Mathieu ^[1]

Afiliação do(s) autor(es)

^[1] Vrije Univ Brussel, Dept In Vitro Toxicol & Dermato Cosmetol, Laarbeeklaan 103, B-1090 Brussels - Belgium

^[2] Vrije Univ Brussel, In Vivo Cellular & Mol Imaging Lab, Laarbeeklaan 103, B-1090 Brussels - Belgium

^[3] Vrije Univ Brussel, Lab Cellular & Mol Immunol, Pleinlaan 2, B-1050 Brussels - Belgium

^[4] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, BR-05508270 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BIOMOLECULES; v. 9, n. 10 OCT 2019.
• Citações Web of Science: 0

Resumo

Adherens junctions, consisting of cadherins and catenins, are a group of cell-to-cell junctions that mediate mechanistic linkage between neighboring cells. By doing so, adherens junctions ensure direct intercellular contact and play an indispensable role in maintaining tissue architecture. Considering these critical functions, it is not surprising that adherens junctions are frequently involved in disease. In the present study, the effects of bile duct ligation-a surgical procedure to experimentally induce cholestatic and fibrotic liver pathology-on hepatic adherens junctions were investigated in mice. In essence, it was found that liver mRNA and protein levels of E-cadherin, beta-catenin and gamma-catenin drastically increase following bile duct ligation. These results could suggest a cytoprotective role for hepatic adherens junctions following bile duct ligation. (AU)

• Processo FAPESP: 13/50420-6 - Canais de conexina e panexina como alvos terapêuticos e biomarcadores nas doenças hepáticas aguda e crônica
• Beneficiário: Mathieu Frederick Alexander Vinken
• Modalidade de apoio: Auxílio à Pesquisa - Programa SPEC