Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni

Autor(es)

Oliveira, Katia C. ^[1] ; Cardoso, Rita ^[2] ; Dos Santos, Antonio C. ^[1] ; Fernandes, Ruben ^{[3, 4]} ; Botelho, Monica C. ^{[2, 4]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, Disciplina Parasitol, Sao Paulo - Brazil

^[2] INSA, Natl Inst Hlth Dr Ricardo Jorge, Dept Hlth Promot & Chron Dis, Porto - Portugal

^[3] Inst Politecn Porto, ESS, Porto - Portugal

^[4] Univ Porto, Inst Invest & Inovacao, I35, Porto - Portugal

• Tipo de documento: Artigo Científico
• Fonte: ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS; v. 19, n. 8, p. 1122-1126, 2019.
• Citações Web of Science: 1

Resumo

Objective: Schistosomiasis is a debilitating disease that affects 200 million people worldwide. Schistosoma haematobium and Schistosoma mansoni are the major causative agents of this disease. Cancer-association and infertility-association in Schistosoma haematobium infection have already been described and it is known that the parasite produces a catechol-estrogen molecule that induces a hormonal imbalance in the host. Methods: In order to better understand the relation of hormonal imbalance in experimental Schistosoma mansoni infection, we investigated a serum panel of steroid hormones in Schistosoma mansoni infected hamsters. Results: We found a decrease in the serum levels of Estradiol (E2), Testosterone and Progesterone in infected females and an increase of Testosterone and a decrease in Progesterone in infected males in comparison with controls. Conclusion: These results indicate that S. mansoni alters the levels of steroid hormones in infected males and females and it will increase the repertoire of data about the host-parasite molecular interplay and its relation with the endocrine system. (AU)

• Processo FAPESP: 12/50115-6 - Estudo das vias de transdução de sinal em Schistosoma mansoni e sua relevância na interação parasita-hospedeiro (schisto-sig)
• Beneficiário: Katia Cristina Pereira Oliveira Santos
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores