| Full text | |
| Author(s): |
Oliveira, Katia C.
[1]
;
Cardoso, Rita
[2]
;
Dos Santos, Antonio C.
[1]
;
Fernandes, Ruben
[3, 4]
;
Botelho, Monica C.
[2, 4]
Total Authors: 5
|
| Affiliation: | [1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, Disciplina Parasitol, Sao Paulo - Brazil
[2] INSA, Natl Inst Hlth Dr Ricardo Jorge, Dept Hlth Promot & Chron Dis, Porto - Portugal
[3] Inst Politecn Porto, ESS, Porto - Portugal
[4] Univ Porto, Inst Invest & Inovacao, I35, Porto - Portugal
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS; v. 19, n. 8, p. 1122-1126, 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
Objective: Schistosomiasis is a debilitating disease that affects 200 million people worldwide. Schistosoma haematobium and Schistosoma mansoni are the major causative agents of this disease. Cancer-association and infertility-association in Schistosoma haematobium infection have already been described and it is known that the parasite produces a catechol-estrogen molecule that induces a hormonal imbalance in the host. Methods: In order to better understand the relation of hormonal imbalance in experimental Schistosoma mansoni infection, we investigated a serum panel of steroid hormones in Schistosoma mansoni infected hamsters. Results: We found a decrease in the serum levels of Estradiol (E2), Testosterone and Progesterone in infected females and an increase of Testosterone and a decrease in Progesterone in infected males in comparison with controls. Conclusion: These results indicate that S. mansoni alters the levels of steroid hormones in infected males and females and it will increase the repertoire of data about the host-parasite molecular interplay and its relation with the endocrine system. (AU) | |
| FAPESP's process: | 12/50115-6 - Study of signal transduction pathways in Schistosoma mansoni and their relevance in the host-pathogen interaction (SchistoSig) |
| Grantee: | Katia Cristina Pereira Oliveira Santos |
| Support Opportunities: | Research Grants - Young Investigators Grants |