Crystal structure, anti-Trypanosoma cruzi and cytotoxic activities of Cu(II) complexes bearing beta-diketone and alpha-diimine ligands

Autor(es):Mostrar menos -

Paixao, Drielly A. ^[1] ; de Oliveira, Barbara C. A. ^[1] ; Almeida, Janaina do Couto ^[1] ; Sousa, Luana M. ^[1] ; Lopes, Carla D. ^[2] ; Carneiro, Zumira A. ^[2] ; Tezuka, Daiane Y. ^[2] ; Clavijo, Juan Carlos T. ^[3] ; Ellena, Javier ^[4] ; Polloni, Lorena ^[5] ; Machado, Pedro H. A. ^[5] ; de Albuquerque, Sergio ^[2] ; de Oliveira Junior, Robson J. ^[5] ; Guilardi, Silvana ^[1] ; Guerra, Wendell ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Uberlandia, Inst Quim, Joao Naves Avila Ave 2121, Campus Santa Mon, BR-38400902 Uberlandia, MG - Brazil

^[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Ribeirao Preto, SP - Brazil

^[3] Univ Estadual Campinas, Inst Quim, Campinas, SP - Brazil

^[4] Univ Sao Paulo, Inst Fis Sao Carlos, Sao Carlos, SP - Brazil

^[5] Univ Fed Uberlandia, Inst Biotecnol, Uberlandia, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Inorganica Chimica Acta; v. 499, JAN 2020.
• Citações Web of Science: 2

Resumo

Three novel copper(II) complexes were synthesized: {[}Cu(tfa)(2)] (I), {[}Cu(tfa)(dmb)(NO3)]center dot 1.5H(2)O (II) and {[}Cu(tfa)(nphen)(NO3)] (III), where tfa = 4,4,4-trifluoro-1-(2-furyl)-1,3-butanedione, nphen = 5-nitro-1,10-phenanthroline and dmb = 4,4-dimethoxy-2,2-bipyridine. They were characterized by elemental analysis, conductivity measurements, FT-IR, UV-Vis and single-crystal X-ray diffraction. The X-ray crystal structures of I, II and III reveal that the beta-diketone coordinates via the oxygen atoms, while the heterocyclic bases coordinate via their two nitrogen atoms. The cytotoxic activity of I, II and III was investigated in two tumor cell lines (Ehrlich tumor and sarcoma 180) and in a non-tumor cell line (myoblast C2C12). Complex DI exhibited good activity (IC50 (Ehrlich) = 15.75 mu M and IC50 (sarcoma )180 = 16.90 mu M) and selectivity (SI > 4) in both tumor cell lines. Subsequently, it was found that III also present good activity against Trypanosoma cruzi. (AU)

• Processo FAPESP: 16/08823-4 - Estudos de Densidade Eletrônica de Fármacos Antirretrovirais como uma ferramenta para o Desenho de Novas Fases Sólidas.
• Beneficiário: Juan Carlos Tenorio Clavijo
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado