Metabolic Alteration and Amyotrophic Lateral Sclerosis Outcome: A Systematic Review

Autor(es)

Brito, Mariana Dutra ^[1] ; Gomes da Silva, Gustavo Ferro ^[1] ; Tilieri, Erick Mutti ^[1] ; Araujo, Beatriz Grisolia ^[1] ; Calio, Michele Longoni ^[2] ; Rosenstock, Tatiana Rosado ^[1]

Afiliação do(s) autor(es)

^[1] Santa Casa Sao Paulo Sch Med Sci, Dept Physiol Sci, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN NEUROLOGY; v. 10, NOV 20 2019.
• Citações Web of Science: 0

Resumo

Background: The development of strategies that could not only efficiently detect the onset of Amyotrophic Lateral Sclerosis (ALS), a fatal neurodegenerative disorder with no cure but also predict its development and evaluate therapeutic intervention would be of great value. In this respect, the metabolic status of ALS patients has called attention. Hence, this study aimed to investigate the potential correlation between changes in ALS's metabolic parameters with the disease outcome in a systematic review. Methods: The manuscripts were manually searched within different databases (PubMed, Web of Science and Cochrane). The inclusion criteria were original articles and reviews about individuals with ALS and its survival, disease prognosis and metabolism (weight, cholesterol, hypertension, BMI, and glycaemia). The authors also established three different exclusion criteria: studies including ALS and other degenerative disorders, works including animal models and published before the year 2000. Results: In total, 29 papers were selected. From all manuscripts, only 82.8% ensured the participation of sALS patients. Also, 27.6% of selected studies described the presence of a genetic mutation. Regarding ALS prognosis, patient's age, the age of ALS onset, ALS duration and survival, <50% of the papers addressed these issues. Specifically, regarding metabolism, 65.5% of articles mentioned BMI, 20.7% mentioned any data concerning hypertension, 6.89% cardiovascular risk, 10.3% obesity, 13.78% diabetes and 10.3% glycaemia. Concerning lipid metabolism, more results were gathered, but still, they did not suffice to establish a correlation with ALS development. Conclusions: Altogether, the authors concluded that available information is not enough to establish a link between ALS and metabolism. In reality, less than half of the manuscripts evaluated show an association between both factors. Nonetheless, it is worth mentioning that metabolism does influence ALS, but not in a unique manner. There is a debate about patients' hypo- and hypermetabolism. Thus, to provide a reliable record, a public policy in which all research and clinical centers might assess the parameters discussed herein is suggested. Accordingly, this systematic review attempts to provide a comprehensible database to facilitate multicentered collaboration, validation, and clinical translation. (AU)

• Processo FAPESP: 15/02041-1 - O papel das lisinas(K)-deacetilases para a neuroproteção de desordens mitocondriais: perspectivas de terapia epigenética para a esclerose lateral amiotrófica e esquizofrenia
• Beneficiário: Tatiana Rosado Rosenstock
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 16/12039-7 - A modulação de lisinas(K)-deacetilases e o seu papel no metabolismo, dinâmica e degradação mitocondrial: possível neuroproteção para a esclerose lateral amiotrófica
• Beneficiário: Mariana Dutra Brito
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 18/09084-6 - Estudo funcional em linfócitos de pacientes com Esclerose Lateral Amiotrófica: relevância para a determinação de biomarcadores
• Beneficiário: Beatriz Grisolia Araujo
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica