Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus

Autor(es):Mostrar menos -

Laurino, Leticia F. ^[1] ; Viroel, Fabia J. M. ^[1] ; Caetano, Erika ^[1] ; Spim, Sara ^[1] ; Pickler, Thaisa B. ^[1] ; Rosa-Castro, Raquel M. ^[1] ; Vasconcelos, Edilma Albuquerque ^[1] ; Jozala, Angela F. ^[1] ; Hataka, Alessandre ^[2] ; Grotto, Denise ^[1] ; Gerenutti, Marli ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sorocaba, BR-18023000 Sorocaba, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Sch Vet Med & Anim Sci, Dept Vet Clin Sci, BR-18610307 Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRIENTS; v. 11, n. 11 NOV 2019.
• Citações Web of Science: 0

Resumo

Background: The presence of beta-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and Lentinus edodes exposure was performed in diabetes mellitus rat model induced by streptozotocin in pre-clinical tests. Methods: On the 20th day of pregnancy, cesarean sections were performed. Blood was collected for biochemical, hematologic parameters and oxidative stress biomarkers. Placenta and amniotic fluid were collected, and fetuses were analyzed through morphological evaluation. Results: The mushroom did not reduce the severe hyperglycemia of the mother-concept but promoted an increase in maternal insulin levels; reduced the levels of alanine aminotransferase, and aspartate aminotransferase, triglyceride and total cholesterol; protected the animals from post-implantation losses. Liver damage induced by streptozotocin was reversed in experimental groups. Conclusions: Lentinus edodes mushroom has antioxidant properties that can minimize the damage caused by gestational diabetes mellitus. (AU)

• Processo FAPESP: 15/24566-9 - Ensaios pré-clínicos com os cogumelos Agaricus blazei, Lentinula edodes e Ganoderma lucidum, visando à redução de danos maternos e fetais causados pelo diabetes gestacional.
• Beneficiário: Marli Gerenutti
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/05765-5 - Avaliação de parâmetros bioquímicos e antioxidantes em ratos expostos ao Lentinula edodes (shiitake), e seu possível uso em distúrbios metabólicos
• Beneficiário: Denise Grotto
• Modalidade de apoio: Auxílio à Pesquisa - Regular