Impact of Inflammation and Treatment on Self-reported Quality of Life in Patients with Non-acute Vogt-Koyanagi-Harada Disease (VKHD)

Autor(es)

Silveira Souto, Fernanda Maria ^[1] ; Brito Goncalves Missaka, Ruy Felippe ^[1] ; Magalhaes, Breno Marchiori ^[1] ; Couto Caetano, Victor Marcos ^[1] ; Takiuti, Julia Thiemi ^[1] ; Lavezzo, Marcelo Mendes ^[1] ; Sakata, Viviane Mayumi ^{[1, 2]} ; Oyamada, Maria Kiyoko ^[1] ; Hirata, Carlos Eduardo ^[1] ; Yamamoto, Joyce Hisae ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med FMUSP, Dept Ophthalmol, LIM 33, Sao Paulo, SP - Brazil

^[2] Univ Fed Parana, Dept Ophthalmol, Curitiba, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: OCULAR IMMUNOLOGY AND INFLAMMATION; v. 29, n. 1 NOV 2019.
• Citações Web of Science: 0

Resumo

Aims: To evaluate associations between vision-related (VR-) and health-related (HR-) QoL metrics and inflammation and treatment in non-acute VKHD patients. Methods: Cross-sectional study in a tertiary center in Sao Paulo, Brazil with 22 patients with non-acute VKHD followed prospectively for >= 12 months since acute disease onset, with systematic evaluation and predefined treatment protocols. VR- and HR-QoL aspects were assessed by VFQ-25 and SF-36 questionnaires, respectively. Associations between the questionnaire's subscale item scores with inflammation and systemic medical therapies were assessed. Results: After generalized linear model analysis, worse VA, severe fundus changes, fluctuation of VA and fluctuation of anterior chamber cells impacted negatively on VR-QoL items. Higher cumulative total dose of corticosteroids and use of immunosuppressive therapy impacted negatively on both questionnaires. Conclusion: Worse VA, clinical inflammation and systemic treatment have a significant impact on VR- and HR-QoL questionnaires. Subclinical choroidal inflammation did not seem to impact QoL. (AU)

• Processo FAPESP: 11/50936-7 - Doença de Vogt-Koyanagi-Harada: parâmetros para tratamento efetivo na fase aguda e no estágio tardio
• Beneficiário: Joyce Hisae Yamamoto Takiuti
• Modalidade de apoio: Auxílio à Pesquisa - Regular