| Full text | |
| Author(s): |
Silveira Souto, Fernanda Maria
[1]
;
Brito Goncalves Missaka, Ruy Felippe
[1]
;
Magalhaes, Breno Marchiori
[1]
;
Couto Caetano, Victor Marcos
[1]
;
Takiuti, Julia Thiemi
[1]
;
Lavezzo, Marcelo Mendes
[1]
;
Sakata, Viviane Mayumi
[1, 2]
;
Oyamada, Maria Kiyoko
[1]
;
Hirata, Carlos Eduardo
[1]
;
Yamamoto, Joyce Hisae
[1]
Total Authors: 10
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med FMUSP, Dept Ophthalmol, LIM 33, Sao Paulo, SP - Brazil
[2] Univ Fed Parana, Dept Ophthalmol, Curitiba, Parana - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | OCULAR IMMUNOLOGY AND INFLAMMATION; v. 29, n. 1 NOV 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Aims: To evaluate associations between vision-related (VR-) and health-related (HR-) QoL metrics and inflammation and treatment in non-acute VKHD patients. Methods: Cross-sectional study in a tertiary center in Sao Paulo, Brazil with 22 patients with non-acute VKHD followed prospectively for >= 12 months since acute disease onset, with systematic evaluation and predefined treatment protocols. VR- and HR-QoL aspects were assessed by VFQ-25 and SF-36 questionnaires, respectively. Associations between the questionnaire's subscale item scores with inflammation and systemic medical therapies were assessed. Results: After generalized linear model analysis, worse VA, severe fundus changes, fluctuation of VA and fluctuation of anterior chamber cells impacted negatively on VR-QoL items. Higher cumulative total dose of corticosteroids and use of immunosuppressive therapy impacted negatively on both questionnaires. Conclusion: Worse VA, clinical inflammation and systemic treatment have a significant impact on VR- and HR-QoL questionnaires. Subclinical choroidal inflammation did not seem to impact QoL. (AU) | |
| FAPESP's process: | 11/50936-7 - Vogt-Koyanagi-Harada disease: parameters for effective treatment in the acute phase and in long-standing disease |
| Grantee: | Joyce Hisae Yamamoto Takiuti |
| Support Opportunities: | Regular Research Grants |