The potential contribution of stromal cell-derived factor 2 (SDF2) in endoplasmic reticulum stress response in severe preeclampsia and labor-onset

Autor(es)

Lorenzon-Ojea, Aline R. ^[1] ; Yung, Hong Wa ^[2] ; Burton, Graham J. ^[2] ; Bevilacqua, Estela ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo, SP - Brazil

^[2] Univ Cambridge, Dept Physiol Dev & Neurosci, Dept Physiol, Cambridge - England

• Tipo de documento: Artigo de Revisão
• Fonte: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE; v. 1866, n. 2 FEB 1 2020.
• Citações Web of Science: 1

Resumo

Endoplasmic reticulum (ER) stress occurs when the protein folding machinery in the cell is unable to cope with newly synthesized proteins, which results in an accumulation of misfolded proteins in the ER lumen. In response, the cell activates a cellular signaling pathway known as the Unfolded Protein Response (UPR), aiming to restore cellular homeostasis. Activation and exacerbation of the UPR have been described in several human pathologies, including cancer and neurological disorders, and in some gestational diseases such as preeclampsia and gestational diabetes. This review explores the participation of stromal cell-derived factor 2 (SDF2) in UPR pathways, shows new information and discusses its exacerbation regarding protein expression in severe preeclampsia and labor, both of which are associated with ER stress. (AU)

• Processo FAPESP: 16/04210-8 - O fator Sdf2 na ativação da rede de sinalização via respostas a proteínas mal enoveladas (UPR) na fisiologia e patologia do trofoblasto
• Beneficiário: Estela Maris Andrade Forell Bevilacqua
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/06824-6 - Expressão de Sdf2 em placenta humana de pacientes com pré-eclâmpsia e diabetes gestacional
• Beneficiário: Aline Rodrigues Lorenzon
• Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 14/13052-1 - O papel do Sdf2 (Stromal Cell Derived Factor 2) na sobrevivência/apoptose de células trofoblásticas via estresse de retículo endoplasmático
• Beneficiário: Aline Rodrigues Lorenzon
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado