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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Docosahexaenoic acid slows inflammation resolution and impairs the quality of healed skin tissue

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Autor(es):
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Candreva, Thamiris [1] ; Kuhl, Carolina M. C. [1] ; Burger, Beatriz [1] ; dos Anjos, Mariah B. P. [1] ; Torsoni, Marcio A. [2] ; Consonni, Silvio R. [3] ; Crisma, Amanda R. [4] ; Fisk, Helena L. [5] ; Calder, Philip C. [6, 7, 5] ; de Mato, Felipe C. P. [8] ; Sernaglia, Erica M. [8] ; Vinolo, Marco A. R. [8] ; Rodrigues, Hosana G. [1]
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Sch Appl Sci, Lab Nutrients & Tissue Repair, Limeira, SP - Brazil
[2] Univ Estadual Campinas, Sch Appl Sci, Lab Metab Disorders, Limeira, SP - Brazil
[3] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP - Brazil
[4] Univ Sao Paulo, Dept Physiol & Biophys, Sao Paulo, SP - Brazil
[5] Univ Southampton, Human Dev & Hlth, Fac Med, Southampton, Hants - England
[6] Univ Southampton, Southampton, Hants - England
[7] Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, Southampton, Hants - England
[8] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Campinas, SP - Brazil
Número total de Afiliações: 8
Tipo de documento: Artigo Científico
Fonte: Clinical Science; v. 133, n. 22, p. 2345-2360, NOV 2019.
Citações Web of Science: 0
Resumo

There is no consensus on the effects of omega-3 (omega-3) fatty acids (FA) on cutaneous repair. To solve this problem, we used 2 different approaches: (1) FAT-1 transgenic mice, capable of producing endogenous omega-3 FA; (2) wild-type (WT) mice orally supplemented with DHA-enriched fish oil. FAT-1 mice had higher systemic (serum) and local (skin tissue) omega-3 FA levels, mainly docosahexaenoic acid (DHA), in comparison with WT mice. FAT-1 mice had increased myeloperoxidase (MPO) activity and content of CXCL-1 and CXCL-2, and reduced IL-10 in the skin wound tissue three days after the wound induction. Inflammation was maintained by an elevated TNF-alpha concentration and presence of inflammatory cells and edema. Neutrophils and macrophages, isolated from FAT-1 mice, also produced increased TNF-alpha and reduced IL-10 levels. In these mice, the wound closure was delayed, with a wound area 6-fold bigger in relation with WT group, on the last day of analysis (14 days post-wounding). This was associated with poor orientation of collagen fibers and structural aspects in repaired tissue. Similarly, DHA group had a delay during late inflammatory phase. This group had increased TNF-alpha content and CD45(+)F4/80(+) cells at the third day after skin wounding and increased concentrations of important metabolites derived from omega-3, like 18-HEPE, and reduced concentrations of those from omega-6 FA. In conclusion, elevated DHA content, achieved in both FAT-1 and DHA groups, slowed inflammation resolution and impaired the quality of healed skin tissue. (AU)

Processo FAPESP: 14/15127-9 - EMU concedido no processo: 2013/06810-4 - citômetro de fluxo BD Accury
Beneficiário:Hosana Gomes Rodrigues
Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
Processo FAPESP: 13/06810-4 - Mecanismos de ação dos ácidos graxos ômega-3 e ômega-6 no processo de reparo tecidual: enfoque neuro-imunológico
Beneficiário:Hosana Gomes Rodrigues
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
Processo FAPESP: 16/02021-3 - Cicatrização de feridas em camundongos FAT-1: envolvimento da via anti-inflamatória colinérgica
Beneficiário:Thamiris Candreva Robles
Modalidade de apoio: Bolsas no Brasil - Mestrado
Processo FAPESP: 16/23298-3 - Análise da composição da fração lipídica fosfatidilcolina em animais fat-1 no contexto da cicatrização de feridas
Beneficiário:Thamiris Candreva Robles
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Mestrado