MicroRNAs: Biological Regulators in Pathogen-Host Interactions

Autor(es)

Acuna, Stephanie Maia ^[1] ; Floeter-Winter, Lucile Maria ^[1] ; Muxel, Sandra Marcia ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Physiol, BR-05508090 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CELLS; v. 9, n. 1 JAN 2020.
• Citações Web of Science: 0

Resumo

An inflammatory response is essential for combating invading pathogens. Several effector components, as well as immune cell populations, are involved in mounting an immune response, thereby destroying pathogenic organisms such as bacteria, fungi, viruses, and parasites. In the past decade, microRNAs (miRNAs), a group of noncoding small RNAs, have emerged as functionally significant regulatory molecules with the significant capability of fine-tuning biological processes. The important role of miRNAs in inflammation and immune responses is highlighted by studies in which the regulation of miRNAs in the host was shown to be related to infectious diseases and associated with the eradication or susceptibility of the infection. Here, we review the biological aspects of microRNAs, focusing on their roles as regulators of gene expression during pathogen-host interactions and their implications in the immune response against Leishmania, Trypanosoma, Toxoplasma, and Plasmodium infectious diseases. (AU)

• Processo FAPESP: 17/23519-2 - Análise do papel de fatores de transcrição e miRNAs na regulação da expressão gênica em macrófagos murinos infectados por Leishmania amazonenses
• Beneficiário: Stephanie Maia Acuna
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 18/23512-0 - A relação Leishmania-hospedeiro sob a ótica das ‘ômicas’
• Beneficiário: Lucile Maria Floeter-Winter
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/24693-9 - Integração dos sinais mediados por fatores de transcrição, long-noncoding RNAs e microRNAs na resposta imune frente a infecção por Leishmania amazonensis
• Beneficiário: Sandra Marcia Muxel
• Modalidade de apoio: Auxílio à Pesquisa - Regular