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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

MicroRNAs: Biological Regulators in Pathogen-Host Interactions

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Author(s):
Acuna, Stephanie Maia [1] ; Floeter-Winter, Lucile Maria [1] ; Muxel, Sandra Marcia [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Dept Physiol, BR-05508090 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: CELLS; v. 9, n. 1 JAN 2020.
Web of Science Citations: 0
Abstract

An inflammatory response is essential for combating invading pathogens. Several effector components, as well as immune cell populations, are involved in mounting an immune response, thereby destroying pathogenic organisms such as bacteria, fungi, viruses, and parasites. In the past decade, microRNAs (miRNAs), a group of noncoding small RNAs, have emerged as functionally significant regulatory molecules with the significant capability of fine-tuning biological processes. The important role of miRNAs in inflammation and immune responses is highlighted by studies in which the regulation of miRNAs in the host was shown to be related to infectious diseases and associated with the eradication or susceptibility of the infection. Here, we review the biological aspects of microRNAs, focusing on their roles as regulators of gene expression during pathogen-host interactions and their implications in the immune response against Leishmania, Trypanosoma, Toxoplasma, and Plasmodium infectious diseases. (AU)

FAPESP's process: 17/23519-2 - Analysis of role of miRNAs and transcription factors on the regulation of gene expression of Leishmania amazonensis infected murine macrophages
Grantee:Stephanie Maia Acuna
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 18/23512-0 - The Leishmania-host relationship from the ‘omics’ perspective
Grantee:Lucile Maria Floeter-Winter
Support type: Research Projects - Thematic Grants
FAPESP's process: 18/24693-9 - Integration of signaling mediated by transcription factors, long-noncoding RNAs and microRNAs during immune response agaisnt Leishmania amazonensis infection
Grantee:Sandra Marcia Muxel
Support type: Regular Research Grants