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The Leishmania-host relationship from the ‘omics’ perspective

Grant number: 18/23512-0
Support type:Research Projects - Thematic Grants
Duration: August 01, 2019 - July 31, 2024
Field of knowledge:Biological Sciences - Parasitology - Protozoology of Parasites
Principal Investigator:Lucile Maria Floeter-Winter
Grantee:Lucile Maria Floeter-Winter
Home Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:Monica Levy Andersen
Assoc. researchers: Angeles López-Gonzálvez ; Audun Helge Nerland ; Coral Barbas ; Eva Gluenz ; Jane Tomimori ; Juliana Ide Aoki ; Karl Erik Müller ; Maria Fernanda Laranjeira da Silva ; Maricruz Mamani Huanca ; Ricardo Andrade Zampieri ; Sandra Marcia Muxel
Associated scholarship(s):20/03186-1 - Sleep fragmentation influence in the Th1/Th2 response to L. amazonensis infection of C57BL/6 mice, BP.IC

Abstract

Leishmania is the protozoan responsible for leishmaniasis, a neglected disease that in Brazil causes about 100,000 new cases per year. In its life cycle, the parasite is found in the midgut of an insect or inside the phagolysosome in the macrophage of the mammalian host. The different stages of parasite life cycle influence the regulation of gene expression, which occurs at post-transcriptional level. Applying genomic, transcriptomic and metabolomic approaches, we will continue, in four subprojects, to study the thematic established by our group, determining and/or establishing new correlations between arginine metabolism and polyamine production in the parasite-host interaction. Thus, we intend to characterize parasites resistant to pentamidine and duramycin, target drugs in polyamine pathways (subproject A). To determine how the infection changes the miRNA profile of human or mice macrophages correlating with transcripts and metabolites profiles (subproject B). To use CRISPR/Cas9 to obtain null knockouts parasites of genes involved in arginine metabolism, confirming physiological roles and the location of their products (subproject C). To correlate sleep fragmentation and consequent alteration of the mounting of immune response against Leishmania infection in C57BL/6 mice, elucidating if there are changes in the profile of transcripts and miRNAs that influence the immune response and the course of infection (subproject D). The challenge of the four sub-projects is to correlate the different aspects of the parasite-host interaction by "omic" analysis, raising points that can be explore the understanding of biology and physiology, and for the design of new strategies to combat the parasite. (AU)

Matéria(s) publicada(s) na Agência FAPESP sobre o auxílio:
A study investigating genetic mechanisms underlying resistance to leishmaniasis 
Articles published in other media outlets (20 total):
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UOL: Fatores genéticos que conferem resistência à leishmaniose são identificados (19/May/2020)
Mais Suas: Pesquisa aponta: mais de 7 milhões de elegíveis para receber a renda básica emergencial não têm acesso à internet (22/May/2020)
LabNetwork: Fatores genéticos que conferem resistência à leishmaniose são identificados (20/May/2020)
Blog Jornal da Mulher: Fatores genéticos que conferem resistência à leishmaniose são identificados (20/May/2020)
NewsLab online: Cientistas brasileiros descrevem fatores genéticos que conferem resistência à leishmaniose (19/May/2020)
JC Notícias (São Paulo, SP): Fatores genéticos que conferem resistência à leishmaniose são identificados (19/May/2020)
Portal da Enfermagem: Fatores genéticos que conferem resistência à leishmaniose são identificados (19/May/2020)
Central das Notícias: Fatores genéticos que conferem resistência à leishmaniose são identificados (19/May/2020)
NCYT Amazings (Espanha): Una investigación muestra los mecanismos genéticos que dotan de resistencia a la leishmaniasis (01/Apr/2020)
Health News: A study investigating genetic mechanisms underlying resistance to leishmaniasis (25/Mar/2020)
Bio1000 (China): Um estudo sobre o mecanismo genético subjacente da anti-leishmaniose (25/Mar/2020)
BioTech.WS: A study investigating genetic mechanisms underlying resistance to leishmaniasis (25/Mar/2020)
pidnews.org: A study investigating genetic mechanisms underlying resistance to leishmaniasis (25/Mar/2020)
Xinkangpm.com: Um estudo sobre o mecanismo genético subjacente da anti-leishmaniose (25/Mar/2020)
News Medical (Austrália): Study explores genetic mechanisms underlying resistance to leishmaniasis (24/Mar/2020)
Bioengineer (Reino Unido): A study investigating genetic mechanisms underlying resistance to leishmaniasis (24/Mar/2020)
Science Codex: A study investigating genetic mechanisms underlying resistance to leishmaniasis (24/Mar/2020)
Scienmag Science Magazine (Reino Unido): A study investigating genetic mechanisms underlying resistance to leishmaniasis (24/Mar/2020)
7thSpace: A study investigating genetic mechanisms underlying resistance to leishmaniasis (24/Mar/2020)
Diwou Biotech News (Austrália): A study investigating genetic mechanisms underlying resistance to leishmaniasis (24/Mar/2020)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HONG, AHYUN; ZAMPIERI, RICARDO ANDRADE; SHAW, JEFFREY JON; FLOETER-WINTER, LUCILE MARIA; LARANJEIRA-SILVA, MARIA FERNANDA. One Health Approach to Leishmaniases: Understanding the Disease Dynamics through Diagnostic Tools. PATHOGENS, v. 9, n. 10 OCT 2020. Web of Science Citations: 0.
ACUNA, STEPHANIE MAIA; FLOETER-WINTER, LUCILE MARIA; MUXEL, SANDRA MARCIA. MicroRNAs: Biological Regulators in Pathogen-Host Interactions. CELLS, v. 9, n. 1 JAN 2020. Web of Science Citations: 0.
MARCIA MUXEL, SANDRA; MAMANI-HUANCA, MARICRUZ; AOKI, JULIANA IDE; ZAMPIERI, RICARDO ANDRADE; FLOETER-WINTER, LUCILE MARIA; LOPEZ-GONZALVEZ, ANGELES; BARBAS, CORAL. Metabolomic Profile of BALB/c Macrophages Infected with Leishmania amazonensis: Deciphering L-Arginine Metabolism. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 24 DEC 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.