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Sleep fragmentation influence in the Th1/Th2 response to L. amazonensis infection of C57BL/6 mice

Grant number: 20/03186-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2020
Effective date (End): August 31, 2021
Field of knowledge:Biological Sciences - Parasitology - Protozoology of Parasites
Principal Investigator:Lucile Maria Floeter-Winter
Grantee:Ana Carolina Miranda Massanet
Home Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:18/23512-0 - The Leishmania-host relationship from the ‘omics’ perspective, AP.TEM

Abstract

To evaluate the effects of sleep fractionation (FS), cytokine production and the profile of miRNAs involved in Th1 and Th2 responses in mice (C57BL / 6) infected by L. amazonensis, mainly miRNA-294, miRNA-721, miRNA -let7e, miRNA-30e and miRNA-302e and their roles in arginine metabolism.