Sleep fragmentation influence in the Th1/Th2 response to L. amazonensis infection of C57BL/6 mice

• Grant number: 20/03186-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2020
• End date: August 31, 2021
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Principal Investigator: Lucile Maria Floeter-Winter
• Grantee: Ana Carolina Miranda Massanet
• Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 18/23512-0 - The Leishmania-host relationship from the ‘omics’ perspective, AP.TEM

Abstract

To evaluate the effects of sleep fractionation (FS), cytokine production and the profile of miRNAs involved in Th1 and Th2 responses in mice (C57BL / 6) infected by L. amazonensis, mainly miRNA-294, miRNA-721, miRNA -let7e, miRNA-30e and miRNA-302e and their roles in arginine metabolism.