Autor(es):Mostrar menos -

Pinto, Ana Jessica ^{[1, 2]} ; Pecanha, Tiago ^{[1, 2]} ; Meireles, Kamila ^{[1, 2]} ; Benatti, Fabiana Braga ^{[3, 1, 2, 4]} ; Bonfiglioli, Karina ^[4] ; de Sa Pinto, Ana Lucia ^{[1, 2, 4]} ; Lima, Fernanda Rodrigues ^{[1, 2, 4]} ; Rodrigues Pereira, Rosa Maria ^[4] ; Costa Irigoyen, Maria Claudia ^[5] ; Turner, James Edward ^[6] ; Kirwan, John P. ^[7] ; Owen, Neville ^{[8, 9]} ; Dunstan, David W. ^{[8, 10]} ; Roschel, Hamilton ^{[1, 2]} ; Gualano, Bruno ^{[1, 2, 4]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Hosp Clin HCFMUSP, Fac Med FMUSP, Av Dr Arnaldo 455, 3 Andar, BR-01246903 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Lab Assessment & Conditioning Rheumatol, Hosp Clin HCFMUSP, Fac Med FMUSP, Av Dr Arnaldo 455, 3 Andar, BR-01246903 Sao Paulo, SP - Brazil

^[3] Univ Estadual Campinas, Sch Appl Sci, R Pedro Zaccaria 1300, BR-13484350 Limeira, SP - Brazil

^[4] Univ Sao Paulo, Rheumatol Div, Fac Med FMUSP, Av Dr Arnaldo 455, BR-05403900 Sao Paulo, SP - Brazil

^[5] Univ Sao Paulo, Fac Med, Heart Inst, Av Dr Eneas Carvalho de Aguiar 44, BR-01246903 Sao Paulo, SP - Brazil

^[6] Univ Bath, Dept Hlth, Claverton Down Rd, Bath BA2 7AY, Avon - England

^[7] Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 - USA

^[8] Baker Heart & Diabet Inst, 99 Commercial Rd, Melbourne, Vic 3004 - Australia

^[9] Swinburne Univ Technol, Ctr Urban Transit, John St, Melbourne, Vic 3122 - Australia

^[10] Australian Catholic Univ, Mary MacKillop Inst Hlth Res, 215 Spring St, Melbourne, Vic 3000 - Australia

• Tipo de documento: Artigo Científico
• Fonte: Trials; v. 21, n. 1 FEB 12 2020.
• Citações Web of Science: 0

Resumo

Background Patients with rheumatoid arthritis spend most of their daily hours in sedentary behavior (sitting), a predisposing factor to poor health-related outcomes and all-cause mortality. Interventions focused on reducing sedentary time could be of novel therapeutic relevance. However, studies addressing this topic remain scarce. We aim to investigate the feasibility and efficacy of a newly developed intervention focused on reducing sedentary time, and potential clinical, physiological, metabolic and molecular effects in rheumatoid arthritis. Methods The Take a STAND for Health study is a 4-month, parallel-group, randomized controlled trial, in which postmenopausal patients with rheumatoid arthritis will set individually tailored, progressive goals to replace their sedentary time with standing and light-intensity activities. Patients will be recruited from the Clinical Hospital (School of Medicine, University of Sao Paulo) and will be assessed at baseline and after a 4-month follow up. Outcomes will include objectively measured sedentary behavior (primary outcome) and physical activity levels, clinical parameters, anthropometric parameters and body composition; aerobic fitness, muscle function, blood pressure, cardiovascular autonomic function, vascular function and structure, health-related quality of life, and food intake. Blood and muscle samples will be collected for assessing potential mechanisms, through targeted and non-targeted approaches. Discussion Findings will be of scientific and clinical relevance with the potential to inform new prescriptions focused on reducing sedentary behavior, a modifiable risk factor that thus far has been overlooked in patients with rheumatoid arthritis. (AU)

• Processo FAPESP: 15/26937-4 - Estudos sobre (in)atividade física em pacientes com artrite reumatóide: caracterização, associações com a doença e efeitos da interrupção do tempo sedentário
• Beneficiário: Ana Jéssica Pinto
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 17/13552-2 - Reduzindo tempo sedentário em populações clínicas: o estudo take a stand for health
• Beneficiário: Bruno Gualano
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/19418-9 - Efeitos agudos e crônicos da redução do tempo sedentário em pacientes com artrite reumatoide: o estudo Take a stand for health
• Beneficiário: Ana Jéssica Pinto
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto
• Processo FAPESP: 16/23319-0 - Disfunção autonômica cardiovascular em pacientes com artrite reumatoide: caracterização, associações com a doença e efeitos da interrupção do tempo sedentário
• Beneficiário: Tiago Peçanha de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado