Complement System in Brain Architecture and Neurodevelopmental Disorders

Autor(es)

Magdalon, Juliana ^{[1, 2]} ; Mansur, Fernanda ^[1] ; Teles e Silva, Andre Luiz ^{[3, 1]} ; de Goes, Vitor Abreu ^{[1, 2]} ; Reiner, Orly ^[4] ; Sertie, Andrea Laurato ^[1]

Afiliação do(s) autor(es)

^[1] Hosp Israelita Albert Einstein, Ctr Expt Res, Sao Paulo - Brazil

^[2] Fac Israelita Ciencias Saude Albert Einstein, Sch Med, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Genet & Evolutionary Biol, Sao Paulo - Brazil

^[4] Weizmann Inst Sci, Dept Mol Genet, Rehovot - Israel

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN NEUROSCIENCE; v. 14, FEB 5 2020.
• Citações Web of Science: 0

Resumo

Current evidence indicates that certain immune molecules such as components of the complement system are directly involved in neurobiological processes related to brain development, including neurogenesis, neuronal migration, synaptic remodeling, and response to prenatal or early postnatal brain insults. Consequently, complement system dysfunction has been increasingly implicated in disorders of neurodevelopmental origin, such as schizophrenia, autism spectrum disorder (ASD) and Rett syndrome. However, the mechanistic evidence for a causal relationship between impaired complement regulation and these disorders varies depending on the disease involved. Also, it is still unclear to what extent altered complement expression plays a role in these disorders through inflammation-independent or -dependent mechanisms. Furthermore, pathogenic mutations in specific complement components have been implicated in the etiology of 3MC syndrome, a rare autosomal recessive developmental disorder. The aims of this review are to discuss the current knowledge on the roles of the complement system in sculpting brain architecture and function during normal development as well as after specific inflammatory insults, such as maternal immune activation (MIA) during pregnancy, and to evaluate the existing evidence associating aberrant complement with developmental brain disorders. (AU)

• Processo FAPESP: 15/50138-4 - Investigação do papel do sistema do complemento no desenvolvimento cerebral e nos Transtornos do Espectro Autista
• Beneficiário: Andréa Laurato Sertié
• Modalidade de apoio: Auxílio à Pesquisa - Regular