Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Hydroquinone exposure alters the morphology of lymphoid organs in vaccinated C57Bl/6 mice

Texto completo
Autor(es):
Fabris, Andre Luis [1] ; Nunes, Andre Vinicius [2] ; Schuch, Viviane [3] ; de Paula-Silva, Marina [1] ; Rocha, G. H. O. [1] ; Nakaya, Helder I. [3] ; Ho, Paulo Lee [4] ; Silveira, Eduardo L. V. [2] ; Poliselli Farsky, Sandra Helena [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Pharmaceut Sci, Lab Expt Toxicol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Pharmaceut Sci, Lab Immunol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Pharmaceut Sci, Computat Syst Biol Lab, Sao Paulo - Brazil
[4] Butantan Inst, Bioind Div, Bacteriol Serv, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Environmental Pollution; v. 257, FEB 2020.
Citações Web of Science: 0
Resumo

The influenza is a common viral infection that can be fatal, especially in high-risk groups such as children, pregnant women, elderly, and immune-deficient individuals. Vaccination is the most efficient approach to prevent the spreading of viral infection and promote individual and public health. In contrast, exposure to environmental pollutants such as cigarette smoke reduces the efficacy of vaccination. We investigated whether chronic exposure to hydroquinone (HQ), the most abundant compound of the tobacco particulate phase, could impair the adaptive immune responses elicited by influenza vaccination. For this, adult male C57BL/6 mice were daily exposed to either nebulized HQ or PBS for 1 h for a total of eight weeks. At weeks 6 and 8, the mice were primed and boosted with the trivalent influenza vaccine via IM respectively. Although the HQ exposure did not alter the body weight of the mice and the biochemical and hematological parameters, the pollutant increased the oxidative stress in splenocytes of immunized animals, modified the morphology of spleen follicles, and augmented the size of their lymph nodes. The lymphoid organs of HQ-exposed mice presented a similar number of vaccine-specific IgG-secreting cells, titers of vaccine-specific total IgG, and respective subclasses. Transcriptome studies with HQ benzene, or cigarette smoke exposure were also analyzed. The genes up-regulated upon pollutant exposure were associated with neutrophil migration and were shown to be co-expressed with antibody-secreting cell genes. Therefore, these findings suggest that HQ exposure may trigger an immune-compensatory mechanism that enhances the humoral responses induced by influenza vaccination. (C) 2019 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 16/24134-4 - Efeito da exposição à hidroquinona sobre a resposta humoral e celular induzido com a imunização com vacina contra influenza
Beneficiário:André Luis Fabris
Modalidade de apoio: Bolsas no Brasil - Mestrado
Processo FAPESP: 14/07328-4 - Identificação de vias endógenas para o controle da inflamação
Beneficiário:Sandra Helena Poliselli Farsky
Modalidade de apoio: Auxílio à Pesquisa - Temático