The Effects of Photobiomodulation on Inflammatory Infiltrate During Muscle Repair in Advanced-Age Rats

Autor(es)

da Silva Junior, Evaldo Moreira ^[1] ; Mesquita-Ferrari, Raquel Agnelli ^{[2, 1]} ; Setubal Destro Rodrigues, Maria Fernanda ^[1] ; Ramos Magalhaes, Eric Moreno ^[3] ; Bussadori, Sandra Kalil ^{[2, 1]} ; De Brito, Adriana ^[1] ; Messias, Felipe de Moura ^[3] ; Costa Souza, Nadhia Helena ^[2] ; Alves, Agnelo Neves ^[1] ; Santos Fernandes, Kristianne Porta ^[1]

Afiliação do(s) autor(es)

^[1] Univ Nove Julho UNINOVE, Postgrad Program Biophoton Appl Hlth Sci, 249 Vergueiro St, BR-01504001 Sao Paulo, SP - Brazil

^[2] Univ Nove Julho UNINOVE, Postgrad Program Rehabil Sci, Sao Paulo - Brazil

^[3] Univ Nove Julho UNINOVE, Hlth Sci Dept, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES; v. 75, n. 3, p. 437-441, MAR 2020.
• Citações Web of Science: 0

Resumo

Photobiomodulation (PBM) enhances muscle repair in aged animals, but its effect on the modulation of the phenotype of immune cells has not yet been determined. Rats (20-month-old) were submitted to cryoinjury of the tibialis anterior muscle and were treated with PBM. After 1, 3, and 7 days, the muscles were submitted to immunohistochemical analysis for the determination of neutrophils and macrophage phenotypes. The muscles treated with PBM exhibited a smaller number of neutrophils after 1 day of treatment and a greater number of both M1 and M2 macrophages after 3 days of treatment. The irradiated tissues exhibited a smaller amount of both macrophage phenotypes after 7 days of treatment. PBM produced temporal alterations in the phenotype of the inflammatory cells during muscle repair process in advanced-age animals, indicating that these mechanisms may contribute to the beneficial effects of this therapy in the treatment of muscle injuries. (AU)

• Processo FAPESP: 13/07502-1 - Efeito da laserterapia sobre a expressão gênica e a produção de citocinas, quimiocinas e fatores de crescimento envolvidos no reparo muscular
• Beneficiário: Kristianne Porta Santos Fernandes
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/12381-1 - Análise comparativa do efeito da laserterapia prévia associada ou não ao tratamento pós sobre a modulação de citocinas inflamatórias, do estresse oxidativo e a determinação do tipo de fibra muscular após lesão aguda
• Beneficiário: Raquel Agnelli Mesquita Ferrari
• Modalidade de apoio: Auxílio à Pesquisa - Regular