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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Effects of Photobiomodulation on Inflammatory Infiltrate During Muscle Repair in Advanced-Age Rats

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Author(s):
da Silva Junior, Evaldo Moreira [1] ; Mesquita-Ferrari, Raquel Agnelli [2, 1] ; Setubal Destro Rodrigues, Maria Fernanda [1] ; Ramos Magalhaes, Eric Moreno [3] ; Bussadori, Sandra Kalil [2, 1] ; De Brito, Adriana [1] ; Messias, Felipe de Moura [3] ; Costa Souza, Nadhia Helena [2] ; Alves, Agnelo Neves [1] ; Santos Fernandes, Kristianne Porta [1]
Total Authors: 10
Affiliation:
[1] Univ Nove Julho UNINOVE, Postgrad Program Biophoton Appl Hlth Sci, 249 Vergueiro St, BR-01504001 Sao Paulo, SP - Brazil
[2] Univ Nove Julho UNINOVE, Postgrad Program Rehabil Sci, Sao Paulo - Brazil
[3] Univ Nove Julho UNINOVE, Hlth Sci Dept, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES; v. 75, n. 3, p. 437-441, MAR 2020.
Web of Science Citations: 0
Abstract

Photobiomodulation (PBM) enhances muscle repair in aged animals, but its effect on the modulation of the phenotype of immune cells has not yet been determined. Rats (20-month-old) were submitted to cryoinjury of the tibialis anterior muscle and were treated with PBM. After 1, 3, and 7 days, the muscles were submitted to immunohistochemical analysis for the determination of neutrophils and macrophage phenotypes. The muscles treated with PBM exhibited a smaller number of neutrophils after 1 day of treatment and a greater number of both M1 and M2 macrophages after 3 days of treatment. The irradiated tissues exhibited a smaller amount of both macrophage phenotypes after 7 days of treatment. PBM produced temporal alterations in the phenotype of the inflammatory cells during muscle repair process in advanced-age animals, indicating that these mechanisms may contribute to the beneficial effects of this therapy in the treatment of muscle injuries. (AU)

FAPESP's process: 13/07502-1 - Effect of laser therapy on gene expression and production of cytokines, chemokines and growth factors involved in muscle repair
Grantee:Kristianne Porta Santos Fernandes
Support Opportunities: Regular Research Grants
FAPESP's process: 14/12381-1 - Comparative analysis of the effect of previous laser therapy associated or not to post treatment on the modulation of inflammatory cytokines, oxidative stress and the determination of muscle fiber type after acute injury
Grantee:Raquel Agnelli Mesquita Ferrari
Support Opportunities: Regular Research Grants