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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Risk factors for obsessive-compulsive symptoms. Follow-up of a community-based youth cohort

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Autor(es):
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Macul Ferreira de Barros, Pedro [1] ; do Rosario, Maria Conceicao [2] ; Szejko, Natalia [3, 4] ; Polga, Natalia [5] ; Requena, Guaraci de Lima [6] ; Ravagnani, Beatriz [1] ; Fatori, Daniel [1] ; Batistuzzo, Marcelo Camargo [1] ; Hoexter, Marcelo Queiroz [1] ; Rohde, Luis Augusto [7] ; Polanczyk, Guilherme Vanoni [1] ; Leckman, James Frederick [8] ; Miguel, Euripedes Constantino [1] ; de Alvarenga, Pedro Gomes [1]
Número total de Autores: 14
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Psychiat, R Dr Ovidio Pires Campos 785, BR-05403903 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Psychiat, Child & Adolescent Psychiat Unit UPIA, Sao Paulo - Brazil
[3] Med Univ Warsaw, Dept Neurol, Warsaw - Poland
[4] Med Univ Warsaw, Dept Bioeth, Warsaw - Poland
[5] Univ Fed Sao Paulo, Grad Program Psychol, Santos, SP - Brazil
[6] Univ Sao Paulo, Inst Math & Stat, Dept Stat, Sao Paulo - Brazil
[7] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS - Brazil
[8] Yale Univ, Sch Med, Yale Child Study Ctr, New Haven, CT - USA
Número total de Afiliações: 8
Tipo de documento: Artigo Científico
Fonte: EUROPEAN CHILD & ADOLESCENT PSYCHIATRY; FEB 2020.
Citações Web of Science: 0
Resumo

Environmental factors are at least as important as genetic factors for the development of obsessive-compulsive symptoms (OCS), but the identification of such factors remain a research priority. Our study aimed to investigate the association between a broad scope of potential risk factors and OCS in a large community cohort of children and adolescents. We evaluated 1877 participants and their caregivers at baseline and after 3 years to assess various demographic, prenatal, perinatal, childhood adversity, and psychopathological factors. Mean age at baseline was 10.2 years (SD 1.9) and mean age at follow-up was 13.4 years (SD 1.9). Reports of OCS at baseline and follow-up were analyzed using latent variable models. At preliminary regression analysis, 15 parameters were significantly associated with higher OCS scores at follow-up. At subsequent regression analysis, we found that eight of these parameters remained significantly associated with higher follow-up OCS scores while being controlled by each other and by baseline OCS scores. The significant predictors of follow-up OCS were: lower socioeconomic status (p = 0.033); lower intelligence quotient (p = 0.013); lower age (p < 0.001); higher maternal stress level during pregnancy (p = 0.028); absence of breastfeeding (p = 0.017); parental baseline OCS (p = 0.038); youth baseline anxiety disorder (p = 0.023); and youth baseline OCS scores (p < 0.001). These findings may better inform clinicians and policymakers engaged in the mental health assessment and prevention in children and adolescents. (AU)

Processo FAPESP: 08/57896-8 - O Instituto Nacional da Psiquiatria do Desenvolvimento: uma nova abordagem para a psiquiatria tendo como foco as nossas crianças e o seu futuro
Beneficiário:Eurípedes Constantino Miguel Filho
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 15/01587-0 - Armazenagem, modelagem e análise de sistemas dinâmicos para aplicações em e-Science
Beneficiário:João Eduardo Ferreira
Linha de fomento: Auxílio à Pesquisa - Programa eScience e Data Science - Temático