Relationship between inflammation and the severity of Recurrent Respiratory Papillomatosis

Autor(es)

Ribeiro El Achkar, Vivian Narana ^[1] ; Duarte, Andressa ^[2] ; Carlos, Roman ^[3] ; Leon, Jorge Esquiche ^[4] ; Ribeiro-Silva, Alfredo ^[5] ; Nagata Pignatari, Shirley Shizue ^[6] ; Kaminagakura, Estela ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, Inst Sci & Technol, Dept Biosci & Oral Diag, UNESP, Sao Jose Dos Campos - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Pathol, Ribeirao Preto - Brazil

^[3] Hosp Herrera Llerandi, Pathol Dept, Guatemala City - Guatemala

^[4] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Stomatol Publ Oral Hlth & Forens Dent, Oral Pathol, Ribeirao Preto - Brazil

^[5] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Pathol & Legal Med, Ribeirao Preto - Brazil

^[6] Sao Paulo Fed Univ, Dept Otorhinolaryngol & Head & Neck Surg, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF OTOLARYNGOLOGY; v. 41, n. 2 MAR-APR 2020.
• Citações Web of Science: 0

Resumo

Objective: To characterize inflammatory cells in Recurrent Respiratory Papillomatosis (RRP) and to correlate it with severity using the Derkay laryngoscopic scale. Materials and methods: The data and biopsies from 36 patients with Juvenile (JRRP) and 56 patients with Adult (ARRP) were collected and analyzed under light microscopy. The patients were separated into groups according to the Derkay index: 20 for the most severe and < 20 for the less severe cases. Immunohistochemical analysis using CD3, CD4, CD8, CD15, CD20, CD68, FoxP3 and MUM-1 antibodies was performed, and the inflammatory cells were quantified. All the clinicopathological characteristics and the results of the immunohistochemical analysis were compared among the groups proposed using the Chi-Square test and correlated through the Spearman correlation test. Results: The ARRP showed significantly higher quantities of CD3 +, CD8 + and MUM1 + cells (p < .05) than the JRRP samples. The presence of CD15 + cells showed positive correlation with the Derkay index (p < .05), while the MUM-1+ cells showed an inverse correlation (p = .01). Conclusion: There are differences between the inflammatory cells population in the juvenile and adult groups and it can be related to disease severity. (AU)

• Processo FAPESP: 16/24019-0 - Investigação da presença de epstein-barr vírus e sua possível contribuição na agressividade e malignização da papilomatose laríngea
• Beneficiário: Estela Kaminagakura Tango
• Modalidade de apoio: Auxílio à Pesquisa - Regular