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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Relationship between inflammation and the severity of Recurrent Respiratory Papillomatosis

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Author(s):
Ribeiro El Achkar, Vivian Narana [1] ; Duarte, Andressa [2] ; Carlos, Roman [3] ; Leon, Jorge Esquiche [4] ; Ribeiro-Silva, Alfredo [5] ; Nagata Pignatari, Shirley Shizue [6] ; Kaminagakura, Estela [1]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ, Inst Sci & Technol, Dept Biosci & Oral Diag, UNESP, Sao Jose Dos Campos - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Pathol, Ribeirao Preto - Brazil
[3] Hosp Herrera Llerandi, Pathol Dept, Guatemala City - Guatemala
[4] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Stomatol Publ Oral Hlth & Forens Dent, Oral Pathol, Ribeirao Preto - Brazil
[5] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Pathol & Legal Med, Ribeirao Preto - Brazil
[6] Sao Paulo Fed Univ, Dept Otorhinolaryngol & Head & Neck Surg, Sao Paulo - Brazil
Total Affiliations: 6
Document type: Journal article
Source: AMERICAN JOURNAL OF OTOLARYNGOLOGY; v. 41, n. 2 MAR-APR 2020.
Web of Science Citations: 0
Abstract

Objective: To characterize inflammatory cells in Recurrent Respiratory Papillomatosis (RRP) and to correlate it with severity using the Derkay laryngoscopic scale. Materials and methods: The data and biopsies from 36 patients with Juvenile (JRRP) and 56 patients with Adult (ARRP) were collected and analyzed under light microscopy. The patients were separated into groups according to the Derkay index: 20 for the most severe and < 20 for the less severe cases. Immunohistochemical analysis using CD3, CD4, CD8, CD15, CD20, CD68, FoxP3 and MUM-1 antibodies was performed, and the inflammatory cells were quantified. All the clinicopathological characteristics and the results of the immunohistochemical analysis were compared among the groups proposed using the Chi-Square test and correlated through the Spearman correlation test. Results: The ARRP showed significantly higher quantities of CD3 +, CD8 + and MUM1 + cells (p < .05) than the JRRP samples. The presence of CD15 + cells showed positive correlation with the Derkay index (p < .05), while the MUM-1+ cells showed an inverse correlation (p = .01). Conclusion: There are differences between the inflammatory cells population in the juvenile and adult groups and it can be related to disease severity. (AU)

FAPESP's process: 16/24019-0 - INVESTIGATION OF THE PRESENCE OF EPSTEIN-BARR VIRUS AND ITS POSSIBLE CONTRIBUTION TO LARYNGEAL PAPILLOMATOSIS AGGRESSIVENESS AND MALIGNIZATION
Grantee:Estela Kaminagakura Tango
Support Opportunities: Regular Research Grants