Systematic Analysis of Monoterpenes: Advances and Challenges in the Treatment of Peptic Ulcer Diseases

Autor(es)

Perico, Larissa Lucena ^[1] ; Emilio-Silva, Maycon Tavares ^[1] ; Ohara, Rie ^[1] ; Rodrigues, Vinicius Peixoto ^[1] ; Bueno, Gabriela ^[1] ; Barbosa-Filho, Jose Maria ^[2] ; Rocha, Lucia Regina Machado da ^[1] ; Batista, Leonia Maria ^[2] ; Hiruma-Lima, Clelia Akiko ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ Unesp, Inst Biosci, Dept Physiol, BR-18618970 Botucatu, SP - Brazil

^[2] Univ Fed Paraiba, Hlth Sci Ctr, Dept Pharmaceut Sci, BR-58051900 Joao Pessoa, Paraiba - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: BIOMOLECULES; v. 10, n. 2 FEB 2020.
• Citações Web of Science: 0

Resumo

Peptic ulcer disease (PUD) is a multifactorial and complex disease caused by an imbalance of protective and aggressive factors (endogenous and exogenous). Despite advances in recent years, it is still responsible for substantial mortality and triggering clinical problems. Over the last decades, the understanding of PUD has changed a lot with the discovery of Helicobacter pylori infection. However, this disease continues to be a challenge due to side-effects, incidence of relapse from use of various anti-ulcer medicines, and the rapid appearance of antimicrobial resistance with current H. pylori therapies. Consequently, there is the need to identify more effective and safe anti-ulcer agents. The search for new therapies with natural products is a viable alternative and has been encouraged. The literature reports the importance of monoterpenes based on the extensive pharmacological action of this class, including wound healing and anti-ulcerogenic agents. In the present study, 20 monoterpenes with anti-ulcerogenic properties were evaluated by assessing recent in vitro and in vivo studies. Here, we review the anti-ulcer effects of monoterpenes against ulcerogenic factors such as ethanol, nonsteroidal anti-inflammatory drugs (NSAIDs), and Helicobacter pylori, highlighting challenges in the field. (AU)

• Processo FAPESP: 18/10935-0 - Avaliação da ação do citral na febre induzida por lipopolissacarídeo em camundongos obesos com dieta hiperlipídica
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• Modalidade de apoio: Bolsas no Brasil - Mestrado
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• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/14797-3 - O papel do extrato hidroalcoólico das folhas de Eugenia punicifolia (Kunth) DC na doença ulcerosa péptica experimental: caracterização dos mecanismos de ação anti-inflamatórios, cicatrizantes e antiapoptóticos.
• Beneficiário: Larissa Lucena Périco
• Modalidade de apoio: Bolsas no Brasil - Doutorado