| Texto completo | |
| Autor(es): Mostrar menos - |
Alibhai, A. Yasin
[1]
;
De Pretto, Lucas R.
[2, 3]
;
Moult, Eric M.
[3]
;
Or, Chris
[1]
;
Arya, Malvika
[1]
;
McGowan, Mitchell
[1]
;
Carrasco-Zevallos, Oscar
[3]
;
Lee, ByungKun
[3]
;
Chen, Siyu
[3]
;
Baumal, Caroline R.
[1]
;
Witkin, Andre J.
[1]
;
Reichel, Elias
[1]
;
de Freitas, Anderson Zanardi
[2]
;
Duker, Jay S.
[1]
;
Fujimoto, James G.
[3]
;
Waheed, Nadia K.
[1]
Número total de Autores: 16
|
| Afiliação do(s) autor(es): | [1] Tufts Med Ctr, New England Eye Ctr, Dept Ophthalmol, Boston, MA 02111 - USA
[2] Nucl & Energy Res Inst IPEN CNEN SP, Ctr Lasers & Applicat, Sao Paulo, SP - Brazil
[3] MIT, Dept Elect Engn & Comp Sci, Res Lab Elect, Cambridge, MA 02139 - USA
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES; v. 40, n. 3, p. 412-420, MAR 2020. |
| Citações Web of Science: | 9 |
| Resumo | |
Purpose: To combine advances in high-speed, wide-field optical coherence tomography angiography (OCTA) with image processing methods for semiautomatic quantitative analysis of capillary nonperfusion in patients with diabetic retinopathy (DR). Methods: Sixty-eight diabetic patients (73 eyes), either without retinopathy or with different degrees of retinopathy, were prospectively recruited for volumetric swept-source OCTA imaging using 12 mm x 12 mm fields centered at the fovea. A custom, semiautomatic software algorithm was used to quantify areas of capillary nonperfusion. Results: The mean percentage of nonperfused area was 0.1% (95% confidence interval: 0.0-0.4) in the eyes without DR; 2.1% (95% confidence interval: 1.2-3.7) in the nonproliferative DR eyes (mild, moderate, and severe), and 8.5% (95% confidence interval: 5.0-14.3) in the proliferative DR eyes. The percentage of nonperfused area increased in a statistically significant manner from eyes without DR, to eyes with nonproliferative DR, to eyes with proliferative DR. Conclusion: Capillary nonperfusion area in the posterior retina increases with increasing DR severity as measured by swept-source OCTA. Quantitative analysis of retinal nonperfusion on wide-field OCTA may be useful for early detection and monitoring of disease in patients with diabetes and DR. (AU) | |
| Processo FAPESP: | 16/17342-0 - Aplicação de técnicas de análise de speckle em OCT para diagnóstico óptico in vivo. |
| Beneficiário: | Lucas Ramos de Pretto |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |
| Processo FAPESP: | 15/15775-3 - Algoritmo para análise de autocorrelação de sinal de tomografia por coerência óptica para acompanhamento de fluxo sanguíneo em camundongos com síndrome metabólica |
| Beneficiário: | Lucas Ramos de Pretto |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |