QUANTIFICATION OF RETINAL CAPILLARY NONPERFUSION IN DIABETICS USING WIDE-FIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

Autor(es):Mostrar menos -

Alibhai, A. Yasin ^[1] ; De Pretto, Lucas R. ^{[2, 3]} ; Moult, Eric M. ^[3] ; Or, Chris ^[1] ; Arya, Malvika ^[1] ; McGowan, Mitchell ^[1] ; Carrasco-Zevallos, Oscar ^[3] ; Lee, ByungKun ^[3] ; Chen, Siyu ^[3] ; Baumal, Caroline R. ^[1] ; Witkin, Andre J. ^[1] ; Reichel, Elias ^[1] ; de Freitas, Anderson Zanardi ^[2] ; Duker, Jay S. ^[1] ; Fujimoto, James G. ^[3] ; Waheed, Nadia K. ^[1]

Afiliação do(s) autor(es)

^[1] Tufts Med Ctr, New England Eye Ctr, Dept Ophthalmol, Boston, MA 02111 - USA

^[2] Nucl & Energy Res Inst IPEN CNEN SP, Ctr Lasers & Applicat, Sao Paulo, SP - Brazil

^[3] MIT, Dept Elect Engn & Comp Sci, Res Lab Elect, Cambridge, MA 02139 - USA

• Tipo de documento: Artigo Científico
• Fonte: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES; v. 40, n. 3, p. 412-420, MAR 2020.
• Citações Web of Science: 9

Resumo

Purpose: To combine advances in high-speed, wide-field optical coherence tomography angiography (OCTA) with image processing methods for semiautomatic quantitative analysis of capillary nonperfusion in patients with diabetic retinopathy (DR). Methods: Sixty-eight diabetic patients (73 eyes), either without retinopathy or with different degrees of retinopathy, were prospectively recruited for volumetric swept-source OCTA imaging using 12 mm x 12 mm fields centered at the fovea. A custom, semiautomatic software algorithm was used to quantify areas of capillary nonperfusion. Results: The mean percentage of nonperfused area was 0.1% (95% confidence interval: 0.0-0.4) in the eyes without DR; 2.1% (95% confidence interval: 1.2-3.7) in the nonproliferative DR eyes (mild, moderate, and severe), and 8.5% (95% confidence interval: 5.0-14.3) in the proliferative DR eyes. The percentage of nonperfused area increased in a statistically significant manner from eyes without DR, to eyes with nonproliferative DR, to eyes with proliferative DR. Conclusion: Capillary nonperfusion area in the posterior retina increases with increasing DR severity as measured by swept-source OCTA. Quantitative analysis of retinal nonperfusion on wide-field OCTA may be useful for early detection and monitoring of disease in patients with diabetes and DR. (AU)

• Processo FAPESP: 16/17342-0 - Aplicação de técnicas de análise de speckle em OCT para diagnóstico óptico in vivo.
• Beneficiário: Lucas Ramos de Pretto
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 15/15775-3 - Algoritmo para análise de autocorrelação de sinal de tomografia por coerência óptica para acompanhamento de fluxo sanguíneo em camundongos com síndrome metabólica
• Beneficiário: Lucas Ramos de Pretto
• Modalidade de apoio: Bolsas no Brasil - Doutorado