| Texto completo | |
| Autor(es): Mostrar menos - |
Babiloni, Claudio
[1, 2]
;
Lopez, Susanna
[1, 3]
;
Del Percio, Claudio
[1]
;
Noce, Giuseppe
[4]
;
Pascarelli, Maria Teresa
[5]
;
Lizio, Roberta
[4]
;
Teipel, Stefan J.
[6, 7]
;
Gonzalez-Escamilla, Gabriel
[8]
;
Bakardjian, Hovagim
[9, 10]
;
George, Nathalie
[11]
;
Cavedo, Enrica
[9, 10, 12]
;
Lista, Simone
[9, 10, 12]
;
Chiesa, Patrizia Andrea
[9, 10, 12]
;
Vergallo, Andrea
[12]
;
Lemercier, Pablo
[9, 10, 12]
;
Spinelli, Giuseppe
[9, 10]
;
Grothe, Michel J.
[6]
;
Potier, Marie-Claude
[10]
;
Stocchi, Fabrizio
[13]
;
Ferri, Raffaele
[5]
;
Habert, Marie-Odile
[14, 15, 16]
;
Fraga, Francisco J.
[17]
;
Dubois, Bruno
[9, 10]
;
Hampel, Harald
[12]
;
Grp, INSIGHT-preAD Study
Número total de Autores: 25
|
| Afiliação do(s) autor(es): Mostrar menos - | [1] Sapienza Univ Rome, Dept Physiol & Pharmacol Erspamer, Rome - Italy
[2] Hosp San Raffaele Cassino, Cassino, FR - Italy
[3] Aldo Moro Univ Bari, Dept Emergency & Organ Transplantat, Nephrol Dialysis & Transplantat Unit, Bari - Italy
[4] IRCCS SDN, Naples - Italy
[5] Oasi Res Inst IRCCS, Troina - Italy
[6] German Ctr Neurodegenerat Dis DZNE Rostock Greifs, Rostock - Germany
[7] Univ Rostock, Dept Psychosomat Med, Rostock - Germany
[8] Johannes Gutenberg Univ Mainz, Dept Neurol, Rhine Main Neurosci Network Rmn2, Focus Program Translat Neurosci FTN, Univ Med Ctr, Mainz - Germany
[9] Hop La Pitie Salpetriere, Inst Memory & Alzheimers Dis IM2A, Dept Neurol, Paris - France
[10] Sorbonne Univ, Inst Cerveau & Moelle Epiniere, INSERM, CNRS, UMR 7225, ICM, U1127, Paris - France
[11] Sorbonne Univ, Ctr NeuroImagerie Rech, Inserm, U1127, CNRS, UMR 7225, Inst Cerveau & Moelle Epiniere, Ctr MEG EEG, ICM, CE, Paris - France
[12] Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, GRC 21, APM, Paris - France
[13] IRCCS San Raffaele Pisana, Rome - Italy
[14] Ctr Acquisit & Traitement Images, CATI Platform, Paris - France
[15] Sorbonne Univ, Lab Imagerie Biomed, INSERM, CNRS, Paris - France
[16] Hop La Pitie Salpetriere, AP HP, Dept Nucl Med, Paris - France
[17] Fed Univ ABC UFABC, CECS Engn Modelling & Appl Social Sci Ctr, Santo Andre, SP - Brazil
Número total de Afiliações: 17
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NEUROBIOLOGY OF AGING; v. 90, p. 43-59, JUN 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Cognitive reserve is present in Alzheimer's disease (AD) seniors with high education attainment making them clinically resilient to extended brain neuropathology and neurodegeneration. Here, we tested whether subjective memory complaint (SMC) seniors with AD neuropathology and high education attainment of the prospective INSIGHT-preAD cohort (Paris) may present abnormal eyes-closed resting state posterior electroencephalographic rhythms around individual alpha frequency peak, typically altered in AD patients. The SMC participants negative to amyloid PET AD markers (SMCneg) with high (over low-moderate) education level showed higher posterior alpha 2 power density (possibly ``neuroprotective{''}). Furthermore, amyloid PET-positive SMC (SMCpos) participants with high (over low-moderate) education level showed higher temporal alpha 3 power density (possibly ``neuroprotective{''}) and lower posterior alpha 2 power density (possibly ``compensatory{''}). This effect may reflect cognitive reserve as no differences in brain gray-white matter, and cognitive functions were observed between these SMCpos/SMCneg subgroups. Preclinical Alzheimer's neuropathology may interact with education attainment and neurophysiological mechanisms generating cortical alpha rhythms around individual alpha frequency peak (i.e., alpha 2 and 3) in quiet wakefulness. (C) 2020 Elsevier Inc. All rights reserved. (AU) | |
| Processo FAPESP: | 18/03655-1 - Biomarcadores de eletroencefalograma baseados em conectividade cerebral para diagnóstico automatizado da Doença de Alzheimer |
| Beneficiário: | Francisco José Fraga da Silva |
| Linha de fomento: | Bolsas no Exterior - Pesquisa |