High levels of proinflammatory cytokines IL-6 and IL-8 are associated with a poor clinical outcome in sickle cell anemia

Autor(es):Mostrar menos -

Domingos, Igor F. ^[1] ; Pereira-Martins, Diego A. ^{[2, 1]} ; Sobreira, Marcondes J. V. C. ^[1] ; Oliveira, Romulo T. D. ^[3] ; Alagbe, Adekunle E. ^[3] ; Lanaro, Carolina ^[4] ; Albuquerque, Dulcineia M. ^[4] ; Blotta, Maria H. S. L. ^[3] ; Araujo, Aderson S. ^[5] ; Costa, Fernando F. ^[4] ; Lucena-Araujo, Antonio R. ^[1] ; Sonati, Maria F. ^[3] ; Bezerra, Marcos A. C. ^[1] ; Santos, Magnun N. N. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Pernambuco, Genet Postgrad Program, Recife, PE - Brazil

^[2] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Internal Med, Sao Paulo - Brazil

^[3] Univ Estadual Campinas, Sch Med Sci, Dept Clin Pathol, UNICAMP, Sao Paulo - Brazil

^[4] Univ Estadual Campinas, Hematol & Hemotherapy Ctr, UNICAMP, Sao Paulo - Brazil

^[5] Fdn Pernambuco, Dept Internal Med Hematol & Hemotherapy, Recife, PE - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ANNALS OF HEMATOLOGY; v. 99, n. 5, p. 947-953, MAY 2020.
• Citações Web of Science: 0

Resumo

Sickle cell anemia (SCA) pathophysiology is characterized by the activation of sickle red blood cells, reticulocytes, leukocytes, platelets, and endothelial cells, and with the expression of several inflammatory molecules. Therefore, it is conceivable that variations in levels of proinflammatory cytokines may act as a signaling of differential clinical course in SCA. Here, we evaluated the clinical impact of proinflammatory cytokines interleukin 1-beta (IL-1 beta), interleukin 6 (IL-6), and interleukin 8 (IL-8) in 79 patients with SCA, followed in a single reference center from northeastern Brazil. The main clinical/laboratory data were obtained from patient interview and medical records. The proinflammatory markers IL-1 beta, IL-6, and IL-8 were evaluated by using commercially available enzyme-linked immunosorbent assay kits. According to levels of the proinflammatory markers, we observed that patients who had a higher frequency of VOC per year (P = 0.0236), acute chest syndrome (P = 0.01), leg ulcers (P = 0.0001), osteonecrosis (P = 0.0006), stroke (P = 0.0486), and priapism (P = 0.0347) had higher IL-6 levels compared with patients without these clinical complications. Furthermore, increased levels of IL-8 were found in patients who presented leg ulcers (P = 0.0184). No significant difference was found for IL-1 beta levels (P > 0.05). In summary, the present study emphasizes the role of inflammation in SCA pathophysiology, reveals an association of IL-8 levels and leg ulcer occurrence, and indicates that IL-6 levels can be used as a useful predictor for poor outcomes in SCA. (AU)

• Processo FAPESP: 14/00984-3 - Doenças dos glóbulos vermelhos: fisiopatologia e novas abordagens terapêuticas
• Beneficiário: Fernando Ferreira Costa
• Modalidade de apoio: Auxílio à Pesquisa - Temático