Hypothalamic IRX3: A New Player in the Development of Obesity

Autor(es)

de Araujo, Thiago Matos ^[1] ; Velloso, Licio A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Obes & Comorbid Res Ctr, Lab Cell Signaling, UNICAMP, Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: TRENDS IN ENDOCRINOLOGY AND METABOLISM; v. 31, n. 5, p. 368-377, MAY 2020.
• Citações Web of Science: 0

Resumo

Genome-wide association studies (GWASs) have identified SNPs of the fat mass and obesity (FTO) gene as the most important risk alleles for obesity. However, how the presence of risk alleles affect phenotype is still a matter of intense investigation. In 2014, a study revealed that long-range enhancers from the intronic regions of the FTO gene regulate iroquois-class homeobox protein (IRX)(3) expression. IRX3 is expressed in hypothalamic pro-opiomelanocortin (POMC) neurons and changes in its expression levels affect body adiposity by modifying food intake and energy expenditure. These findings have placed IRX3 as a potential target for the treatment of obesity. Here, we review studies that evaluated the roles of IRX3 in development, neurogenesis, and body energy homeostasis. (AU)

• Processo FAPESP: 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas
• Beneficiário: Licio Augusto Velloso
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs