Beyond the metabolic syndrome: Visceral and marrow adipose tissues impair bone quantity and quality in Cushing's disease

Autor(es):Mostrar menos -

Batista, Sergio Luchini ^[1] ; de Araujo, Iana Mizumukai ^[1] ; Carvalho, Adriana Lelis ^[1] ; Alencar, Maria Augusta V. S. D. ^[1] ; Nahas, Andressa K. ^[2] ; Elias Jr, Jorge ; Nogueira-Barbosa, Marcello H. ^[3] ; Salmon, Carlos E. G. ^[4] ; Elias, Paula C. L. ^[3] ; Moreira, Ayrton C. ^[3] ; Castro, Margaret ^[3] ; de Paula, Francisco J. A. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Clin Med, Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Fac Publ Hlth, Sao Paulo, SP - Brazil

^[3] Elias Jr, Jr., Jorge, Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Clin Med, Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, Dept Phys, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 14, n. 10 OCT 15 2019.
• Citações Web of Science: 1

Resumo

The present study was designed to evaluate the relationship between bone traits {[}bone mineral density (BMD) and trabecular bone score (TBS)] and the accumulation of fat in adipose tissues {[}abdominal subcutaneous (SAT), visceral (VAT), marrow (MAT) and intrahepatic lipids (IHL)], as well as insulin resistance, in subjects with Cushing's disease (CD). The study included control (C = 27), paired (P = 16) and Cushing's disease (CD = 10) groups, which underwent biochemical assessment, dual X-ray absorptiometry, TBS, and magnetic resonance imaging to determine fat deposits. The CD group showed higher serum levels of glucose and insulin, as well as HOMA-IR values, but lower circulatory levels of osteocalcin, in comparison to C and P. The CD group exhibited lower L1-L4 BMD than P (P = 1.059 +/- 0.141 vs CD = 0.935 +/- 0.093 g/cm(2), p < 0.05) (Fig 1A). The lumbar spine BMD from the C group was similar to the other groups. TBS was lower in CD than in P and C (C = 1.512 +/- 0.077 vs P = 1.405 +/- 0.150 vs CD = 1.135 +/- 0.136; p<0.05); there was also significant difference between C and P (p<0.05). MAT, VAT, and IHL were higher in CD than in C and P (p<0.05). Considering all subjects, there was a positive association between TBS with both lumbar spine BMD (R-2 = 0.45; p<0.0001) and osteocalcin (R-2 = 0.44; p = 0.05). TBS was negatively associated with MAT (R-2 = 0.49; p = 0.01), VAT (R-2 = 0.55; p<0.05), and HOMA-IR (R-2 = 0.44; p<0.01). MAT was positively related with VAT (R-2 = 0.44; p<0.01) and IHL (R-2 = 0.41; p<0.05). In CD, insulin resistance and adipose tissue dysfunction, including high MAT, are active players in bone deterioration, as confirmed by lower lumbar spine BMD and lower TBS. Thus, our findings point to an additional component of the already well-known complex mechanisms of osteoporosis associated with hypercortisolism. (AU)

• Processo FAPESP: 16/18574-1 - Aplicação da ressonância magnética para estudo quantitativo da microarquitetura óssea e sua relação com o acúmulo de gordura muscular e óssea no diabetes mellitus tipo 2
• Beneficiário: Iana Mizumukai de Araujo
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/14060-9 - Aplicação da ressonância magnética para estudo quantitativo da microarquitetura óssea e sua relação com o acúmulo de gordura muscular e óssea no diabetes melito tipo 2
• Beneficiário: Francisco José Albuquerque de Paula
• Modalidade de apoio: Auxílio à Pesquisa - Regular