Distinct Salivary Gland Features in Sjogren's Syndrome and Lupus Erythematosus Sialadenite

Autor(es)

Bologna, Sheyla B. ^[1] ; Cavalcante, Wanessa S. ^[2] ; Florezi, Giovanna P. ^[1] ; Souza, Milena M. ^{[3, 2]} ; Nico, Marcello M. S. ^[2] ; Lourenco, Silvia V. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dent Sch, Dept Stomatol, Av Prof Lineu Prestes 2227, BR-05508000 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Med Sch, Dept Dermatol, Sao Paulo - Brazil

^[3] AC Camargo Canc Ctr, Int Res Ctr, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF DERMATOPATHOLOGY; v. 42, n. 6, p. 407-413, JUN 2020.
• Citações Web of Science: 0

Resumo

Background: Primary Sjogren's syndrome (pSS) is an important cause of xerostomia, and the presence of this symptom in lupus erythematosus (LE) is usually referred to as secondary SS. Although these diseases share many clinical and laboratory aspects, the histopathological changes of minor salivary glands (MSG) have been widely evaluated to determine whether this damage is specific for each disease. Based on this query, the aim of this study was to analyze morphological findings of minor salivary glands in pSS or LE. Methods: Two groups of 30 (MSG) from patients with pSS and LE were histopathologically evaluated, and the results were statistically analyzed using the two-tailed Fisher exact test. Results: The morphological changes were distinct among the groups and statistically significant. In pSS, the most evident features were the focal lymphocytic ductal aggression, with the focus score >= 1 and the periductal fibroplasia, while in LE, perivascular inflammatory infiltrate, spongiosis of ductal cells not associated with the exocytosis, and hyalinization of the periductal basement membrane were detected. Conclusions: These results indicated that in each disorder, MSG have their specific morphological changes, which lead to xerostomia, and the impairment of MSG in LE is probably due to a lupus sialadenitis. (AU)

• Processo FAPESP: 14/15214-9 - Sialadenite na Síndrome de Sjogren x Sialadenite lúpica: correlação clínico-patológica e análise proteômica da saliva
• Beneficiário: Sheyla Batista Bologna Lopes
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/11806-7 - Sialadenite na síndrome de Sjögren e no lúpus eritematoso: correlação clínico-patológica e análises proteômica e metabolômica da saliva
• Beneficiário: Silvia Vanessa Lourenço
• Modalidade de apoio: Auxílio à Pesquisa - Regular