Presence of Colistin Resistancemcr-4Gene and Clinically Relevant Antimicrobial Resistance Genes in Sand Samples from a Public Beach

Autor(es)

Rueda Furlan, Joao Pedro ^[1] ; Rodrigues dos Santos, Lucas David ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Analises Clin Toxicol & Bromatol, Ribeirao Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: WATER AIR AND SOIL POLLUTION; v. 231, n. 7 JUN 17 2020.
• Citações Web of Science: 0

Resumo

The plasmid-borne mobilized colistin resistance genes (mcr-like) are related to resistance to polymyxins, which were reintroduced for the treatment of infections caused by multidrug-resistant pathogens. To analyze the presence of clinically relevant antimicrobial resistance genes (ARGs), includingmcr-like genes and plasmids in a beach, sand samples from a public beach were collected. Fifty-seven amplicons from 22 ARGs [mcr-4,bla(VIM),bla(CTX-M-Gp9),bla(PER),bla(CMY),qnrB,qnrS,oqxA,oqxB,sul1,sul2,sul3,floR,cmlA,tetA,tetB,tetC,aadA,ant(2 '')-Ia,aph(3 ')-Ib,aac(6 ')-Ib, andmefAE] and 18 amplicons from seven plasmid families (IncF(repB), IncFIA, IncHI1, IncFIB, IncY, IncN, and ColE-like) were detected. To the best of our knowledge, this is the first report of themcr-4gene in Brazil and the first report in the world ofmcr-4gene in a recreation area. This study calls attention to the presence ofmcr-4gene and contribute to the surveillance studies about themcr-like genes. (AU)

• Processo FAPESP: 18/01890-3 - Estudo do perfil de resistência, virulência e epidemiológico de Escherichia coli isoladas do meio ambiente
• Beneficiário: João Pedro Rueda Furlan
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/19539-0 - Caracterização molecular de isolados de Escherichia coli provenientes do meio ambiente
• Beneficiário: Eliana Guedes Stehling
• Modalidade de apoio: Auxílio à Pesquisa - Regular