| Texto completo | |
| Autor(es): |
Furtado, Cristiana Libardi Miranda
[1, 2]
;
Iannetta, Renata
[1]
;
Ferriani, Rui Alberto
[1]
;
Silva, Ana Carolina J. S.
[1]
;
Martinelli, Carlos Eduardo
[3]
;
Calado, Rodrigo Tocantins
[4]
;
dos Reis, Rosana Maria
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Gynecol & Obstet, Ribeirao Preto - Brazil
[2] Univ Fed Ceara, Postgrad Program Med & Surg Sci, Drug Res & Dev Ctr, Fortaleza, Ceara - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pediat, Sao Paulo - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Med Images Hematol & Clin Oncol, Ribeirao Preto - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Gynecological Endocrinology; v. 36, n. 12 JUN 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Background:Idiopathic central precocious puberty (iCPP) presents a disproportionate advancement of bone age and maturation, as well as metabolic and endocrinological changes that may be related to effects on telomere biology. Objective:To investigate the telomere length in iCPP girls treated with GnRHa. Study design:Observational case-control study with 85 girls, including 45 iCPP treated with GnRHa and 40 controls. It was analyzed age, height, weight and body mass index (BMI), insulin, triglycerides, testosterone, insulin resistance by HOMA, and telomere length by real-time PCR. Statistical analyses were determined by Wilcoxon test and Spearman correlation was carried out. Results:Weight, BMI, insulin level and HOMA index were higher in the iCPP than in the control group (p < .01); without difference between mean ages. The telomere length did not differ between iCPP and control group. However, a negative correlation was observed between the telomere length and age in iCPP (p = .0009) and control group (p = .014), and weight in the iCPP (p = .017). Conclusions:We did not observe any difference in the telomere length in the iCPP and control group. Even though, some characteristics of the disease, such as increased weight and body fat, negatively influence the telomere biology. (AU) | |
| Processo FAPESP: | 12/11566-2 - Polimorfismo cag do receptor de andrógenos e comprimento do telômero em pacientes com falência ovariana prematura |
| Beneficiário: | Rosana Maria dos Reis |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 12/11069-9 - Polimorfismo cag do receptor de andrógenos e comprimento do telômero em pacientes com falência ovariana prematura |
| Beneficiário: | Cristiana Libardi Miranda Furtado |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |