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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Telomere length is not altered in girls with idiopathic central precocious puberty treated with a GnRH analog - leuprolide acetate

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Author(s):
Furtado, Cristiana Libardi Miranda [1, 2] ; Iannetta, Renata [1] ; Ferriani, Rui Alberto [1] ; Silva, Ana Carolina J. S. [1] ; Martinelli, Carlos Eduardo [3] ; Calado, Rodrigo Tocantins [4] ; dos Reis, Rosana Maria [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Gynecol & Obstet, Ribeirao Preto - Brazil
[2] Univ Fed Ceara, Postgrad Program Med & Surg Sci, Drug Res & Dev Ctr, Fortaleza, Ceara - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pediat, Sao Paulo - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Med Images Hematol & Clin Oncol, Ribeirao Preto - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Gynecological Endocrinology; v. 36, n. 12 JUN 2020.
Web of Science Citations: 0
Abstract

Background:Idiopathic central precocious puberty (iCPP) presents a disproportionate advancement of bone age and maturation, as well as metabolic and endocrinological changes that may be related to effects on telomere biology. Objective:To investigate the telomere length in iCPP girls treated with GnRHa. Study design:Observational case-control study with 85 girls, including 45 iCPP treated with GnRHa and 40 controls. It was analyzed age, height, weight and body mass index (BMI), insulin, triglycerides, testosterone, insulin resistance by HOMA, and telomere length by real-time PCR. Statistical analyses were determined by Wilcoxon test and Spearman correlation was carried out. Results:Weight, BMI, insulin level and HOMA index were higher in the iCPP than in the control group (p < .01); without difference between mean ages. The telomere length did not differ between iCPP and control group. However, a negative correlation was observed between the telomere length and age in iCPP (p = .0009) and control group (p = .014), and weight in the iCPP (p = .017). Conclusions:We did not observe any difference in the telomere length in the iCPP and control group. Even though, some characteristics of the disease, such as increased weight and body fat, negatively influence the telomere biology. (AU)

FAPESP's process: 12/11566-2 - ANDROGEN RECEPTOR CAG POLIMORFISM AND TELOMERE LENGTH IN PREMATURE OVARIAN FAILURE
Grantee:Rosana Maria dos Reis
Support Opportunities: Regular Research Grants
FAPESP's process: 12/11069-9 - ANDROGEN RECEPTOR CAG POLIMORFISM AND TELOMERE LENGTH IN PREMATURE OVARIAN FAILURE
Grantee:Cristiana Libardi Miranda Furtado
Support Opportunities: Scholarships in Brazil - Post-Doctoral