Comparative analysis of two models (Bayley-Pinneau tables vs mathematical model) for predicting adult height of girls with idiopathic central precocious puberty

• Grant number: 15/22074-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2016
• End date: September 30, 2016
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Vinicius Nahime de Brito
• Grantee: Mateus Cavarzan Lopes
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Precocious puberty is defined as the development of sexual characteristics in girls before the age of 8 years. It can be classified as central precocious puberty (CPP) when it is due to the premature activation of the gonadotropic axis and as idiopathic (ICPP), when there is no lesion in the central nervous system. Treatment with gonadotropin-releasing hormone analogs (GnRHa) is the first-line therapy for CPP. Common reasons for indicating GnRHa therapy are potential compromise of adult height, inability to adapt oneself to menarche and psychosocial difficulties. Guidelines for CPP treatment are controversial in regard to compromise in adult stature. Girls with onset of ICPP and treatment before 6 years of age benefit most in terms of adult height. In contrast, girls who develop CPP and are treated between 6-8 years of age represent a heterogeneous group with variable outcome. Finally, after 8 years of age, treatment does not improve adult height prognosis and its indication must be individualized. If not treated, progressive ICPP may result in short stature. The Bayley-Pinneau method is commonly used to predict adult height; however, because it was based on normal cases, it overpredicts height by several centimeters in patients with ICPP. Recently, Giambicani E et al proposed a new method, based on a mathematical model that includes chronological age at onset of puberty, parents' heights (reinforcing the genetic influence on adult height) and LH/FSH peaks ratio, whose formula is available for validation in other cohorts. Our aim is to compare both methods through a retrospective study in treated ICPP girls.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MATEUS CAVARZAN LOPES; CAROLINA OLIVEIRA RAMOS; ANA CLAUDIA LATRONICO; BERENICE B. MENDONÇA; VINICIUS N. BRITO. Applicability of a novel mathematical model for the prediction of adult height and age at menarche in girls with idiopathic central precocious puberty. Clinics, v. 73, 2018-07-26. (15/22074-1)