Recent Advances in the Synthesis of Enantiomerically Enriched Diaryl, Aryl Heteroaryl, and Diheteroaryl Alcohols through Addition of Organometallic Reagents to Carbonyl Compounds

Autor(es)

Teixeira, Wystan K. O. ^[1] ; de Albuquerque, Danilo Yano ^[1] ; Narayanaperumal, Senthil ^[2] ; Schwab, Ricardo S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos UFSCar, Ctr Excellence Res Sustainable Chem CERSusChem, Dept Quim, Rodovia Washington Luis, Km 235, SP 310, BR-13565905 Sao Carlos, SP - Brazil

^[2] Dayananda SagarAcad Technol & Management DSATM, Dept Chem, Kanakapura Rd, Bengaluru 560082 - India

• Tipo de documento: Artigo de Revisão
• Fonte: SYNTHESIS-STUTTGART; v. 52, n. 13, p. 1855-1873, JUL 1 2020.
• Citações Web of Science: 0

Resumo

Enantiomerically enriched diaryl, aryl heteroaryl, and dihetero-aryl alcohols are an important family of compounds known for their biological properties. Moreover, these molecules are highly privileged scaffolds used as building blocks for the synthesis of pharmaceutically relevant products. This short review provides background on the enantioselective arylation and heteroarylation of carbonyl compounds, as well as, the most significant improvements in this field with special emphasis on the application of organometallic reagents. 1 Introduction 2 Background on the Enantioselective Synthesis of Diaryl, Aryl Heteroaryl, and Diheteroaryl Alcohols 3Organozinc Reagents 4 Organolithium Reagents 5 Grignard Reagents 6 Organoaluminum Reagents 7 Organotitanium Reagents 8 Organobismuth Reagents 9 Miscellaneous 10 Conclusion (AU)

• Processo FAPESP: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
• Beneficiário: Arlene Gonçalves Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Programa Centros de Pesquisa em Engenharia
• Processo FAPESP: 13/06558-3 - Catálise metálica assimétrica: preparação de alcoóis quirais e seus derivados a partir de reagentes orgânicos de zinco poli-funcionalizados e aplicação de novos ligantes quirais suportados em nanopartículas magnéticas
• Beneficiário: Ricardo Samuel Schwab
• Modalidade de apoio: Auxílio à Pesquisa - Regular