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Socioeconomic status in children is associated with spontaneous activity in right superior temporal gyrus

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Autor(es):
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Biazoli Jr, Claudinei Eduardo ; Salum, Giovanni Abrahao [1, 2, 3] ; Gadelha, Ary [2, 4] ; Rebello, Keila [5] ; Moura, Luciana Monteiro [2, 4] ; Pan, Pedro Mario [2, 4] ; Brietzke, Elisa [2, 4] ; Miguel, Euripedes Constantino [2, 6] ; Rohde, Luis Augusto [1, 2, 3] ; Bressan, Rodrigo Affonseca [2, 4] ; Jackowski, Andrea Parolin [2, 4] ; Sato, Joao Ricardo [2, 5]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Univ Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS - Brazil
[2] CNPq, Natl Inst Dev Psychiat Children & Adolescents, Sao Paulo - Brazil
[3] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS - Brazil
[4] Univ Fed Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo, SP - Brazil
[5] Biazoli Jr, Jr., Claudinei Eduardo, Univ Fed ABC, Ctr Math Comp & Cognit, Av Estados 5001, BR-09210580 Santo Andre, SP - Brazil
[6] Univ Sao Paulo, Sch Med, Dept Psychiat, Sao Paulo - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: BRAIN IMAGING AND BEHAVIOR; v. 14, n. 4, p. 961-970, AUG 2020.
Citações Web of Science: 1
Resumo

Socioeconomic status (SES) during childhood is a well-documented life-course health determinant. Despite recent advances on characterizing brain structural variance associated with SES during development, how it influences brain's functional organization remains elusive. Associations between SES, an fMRI feature of regional spontaneous activity (fractional amplitude of low frequencies fluctuation, fALFF), and behavioral/emotional problems were investigated in a school-based sample of 655 Brazilian children. A voxel-by-voxel approach was applied in order to map brain regions where fALFF was correlated with SES. Based on compelling previous evidence, we hypothesized that fALFF should be associated with SES in areas involved in language processing or cognitive control. Further, we tested if the spontaneous activity in these mapped areas would also correlated with general, internalizing and externalizing problems. SES of children was found to be positively correlated with spontaneous activity in right superior temporal gyrus. In the exploratory analysis, the fALFF of this area was negatively correlated with the expression of internalizing problems. Extending previous behavioral and structural neuroimaging findings, we report an association between SES and the spontaneous activity of a brain area enrolled in the extended language network. This finding is consistent with the hypothesis that the variability on linguistic environment according to SES lead to different developmental trajectories of functional networks instantiating language. (AU)

Processo FAPESP: 13/08531-5 - Coorte de alto risco para transtornos psiquiátricos na infância: seguimento de neuroimagem após 3 anos
Beneficiário:Andrea Parolin Jackowski
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/10498-6 - Aprendizado de máquina em neuroimagem: desenvolvimento de métodos e aplicações clínicas em transtornos psiquiátricos
Beneficiário:João Ricardo Sato
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/57896-8 - O Instituto Nacional da Psiquiatria do Desenvolvimento: uma nova abordagem para a psiquiatria tendo como foco as nossas crianças e o seu futuro
Beneficiário:Eurípedes Constantino Miguel Filho
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 13/00506-1 - Séries temporais, ondaletas e análise de dados funcionais
Beneficiário:Pedro Alberto Morettin
Linha de fomento: Auxílio à Pesquisa - Temático