Progesterone decreases ovarian cancer cells migration and invasion

Autor(es)

Lima, Maira A. ^[1] ; Silva, V, Suely ; Jaeger, Ruy G. ^[2] ; Freitas, Vanessa M. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Biol Celular & Desenvolvimento, Av Prof Lineu Prestes 1524, Ed Biomed 1 Sala 428, BR-05508000 Sao Paulo, SP - Brazil

^[2] Silva, Suely, V, Univ Sao Paulo, Inst Ciencias Biomed, Dept Biol Celular & Desenvolvimento, Av Prof Lineu Prestes 1524, Ed Biomed 1 Sala 428, BR-05508000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Steroids; v. 161, SEP 2020.
• Citações Web of Science: 0

Resumo

The progression of cancer depends on the interaction between the cells and their microenvironment. Progesterone is a steroid and progestogen sex hormone produced by the corpus luteum, which is a transitory endocrine gland in female mammals and prepares the endometrium for implantation. Also, progesterone is involved in antitumorigenic process in different types of cancer. Our goal is to investigate the role of progesterone in cell invasion and migration. Ovarian cells were treated with different concentrations of progesterone. 500 nM or 1 mu M progesterone decreased the migration of the cells in 24 h or less without affecting the viability. Immunoblot showed that treatment with 1 mu M progesterone decreased the phosphorylated forms of Src and FAK, and the cells were less polarized. Our results suggest that progesterone interferes with migration and invasion of ovarian cells. Inhibitory experiments inferred the progesterone receptor playing a role in migration and invasion. Decreased phosphorylation of molecules involved in these processes was also found. (AU)

• Processo FAPESP: 18/19813-5 - Função da progesterona e da protease ADAMTS 1 na migração de células derivadas de câncer de ovário
• Beneficiário: Maíra de Assis Lima
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 18/05566-6 - ADAMTS-1 nuclear regulando o comportamento de células normais e neoplásicas
• Beneficiário: Vanessa Morais Freitas
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/19773-5 - Função da progesterona e da protease ADAMTS 1 na migração de células derivadas de câncer de ovário
• Beneficiário: Maíra de Assis Lima
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 10/07699-1 - Protease ADAMTS-1 influenciando o comportamento e o microambiente do câncer de mama
• Beneficiário: Vanessa Morais Freitas
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores