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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Progesterone decreases ovarian cancer cells migration and invasion

Full text
Author(s):
Lima, Maira A. [1] ; Silva, V, Suely ; Jaeger, Ruy G. [2] ; Freitas, Vanessa M. [2]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Biol Celular & Desenvolvimento, Av Prof Lineu Prestes 1524, Ed Biomed 1 Sala 428, BR-05508000 Sao Paulo, SP - Brazil
[2] Silva, Suely, V, Univ Sao Paulo, Inst Ciencias Biomed, Dept Biol Celular & Desenvolvimento, Av Prof Lineu Prestes 1524, Ed Biomed 1 Sala 428, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Steroids; v. 161, SEP 2020.
Web of Science Citations: 0
Abstract

The progression of cancer depends on the interaction between the cells and their microenvironment. Progesterone is a steroid and progestogen sex hormone produced by the corpus luteum, which is a transitory endocrine gland in female mammals and prepares the endometrium for implantation. Also, progesterone is involved in antitumorigenic process in different types of cancer. Our goal is to investigate the role of progesterone in cell invasion and migration. Ovarian cells were treated with different concentrations of progesterone. 500 nM or 1 mu M progesterone decreased the migration of the cells in 24 h or less without affecting the viability. Immunoblot showed that treatment with 1 mu M progesterone decreased the phosphorylated forms of Src and FAK, and the cells were less polarized. Our results suggest that progesterone interferes with migration and invasion of ovarian cells. Inhibitory experiments inferred the progesterone receptor playing a role in migration and invasion. Decreased phosphorylation of molecules involved in these processes was also found. (AU)

FAPESP's process: 18/19813-5 - Function of progesterone and ADAMTS 1 in the migration of cells derived from ovarian cancer
Grantee:Maíra de Assis Lima
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 18/05566-6 - Nuclear ADAMTS-1 regulating normal and cancer cells
Grantee:Vanessa Morais Freitas
Support Opportunities: Regular Research Grants
FAPESP's process: 15/19773-5 - Functions of progesterone and ADAMTS 1 protease in the migration of cells derived from ovarian cancer
Grantee:Maíra de Assis Lima
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 10/07699-1 - Protease ADAMTS1 influencing breast cancer behavior and microenvironment
Grantee:Vanessa Morais Freitas
Support Opportunities: Research Grants - Young Investigators Grants