Fatal pulmonary sporotrichosis caused by Sporothrix brasiliensis in Northeast Brazil

Autor(es):Mostrar menos -

Alves, Manoella do Monte ^[1] ; Milan, Eveline Pipolo ^[1] ; da Silva-Rocha, Walicyranison Plinio ^[2] ; de Sena da Costa, Alexandre Soares ^[2] ; Macielid, Bruno Araujo ^[3] ; Cavalcante Vale, Pedro Henrique ^[3] ; de Albuquerque, Paulo Roberto ^[3] ; Lima, Soraia Lopes ^[4] ; de Azevedo Melo, Analy Salles ^[4] ; Rodrigues, Anderson Messias ^[5] ; Chaves, Guilherme Maranhao ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Rio Grande do Norte, Inst Med Trop, Dept Infectol, Natal, RN - Brazil

^[2] Univ Fed Rio Grande do Norte, Lab Micol Med & Mol, Dept Anal Clin & Toxicol, Natal, RN - Brazil

^[3] Univ Fed Rio Grande do Norte, Hosp Univ Onofre Lopes, Natal, RN - Brazil

^[4] Univ Fed Sao Paulo, Disciplina Infectol, Lab Especial Micol, Sao Paulo - Brazil

^[5] Univ Fed Sao Paulo, Lab Fungos Patogen Emergentes, Div Biol Celular, Dept Microbiol Imunobiol & Parasitol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS Neglected Tropical Diseases; v. 14, n. 5 MAY 2020.
• Citações Web of Science: 0

Resumo

Background A relevant case of pulmonary sporotrichosis due to Sporothrix brasiliensis is reported in a 50-year-old immunocompetent woman who had no history of skin trauma, but was in close contact with several stray cats at her nap time. The patient was hospitalized after 7 months of illness. The survey was conducted for pulmonary tuberculosis, an endemic disease in Brazil. She presented multiple central pulmonary nodules images, with central cavitation. Methodology/Principal findings The patient bronchoalveolar lavage was cultured and Sporothrix sp. growth was obtained. Then, the isolate (LMMM1097) was accurately identified to the species level by using species-specific polymerase chain reaction (PCR). Molecular diagnosis revealed that the emerging species Sporothrix brasiliensis was the agent of primary pulmonary sporotrichosis and the patient was treated with Amphotericin B lipid complex, but presented severe clinical symptoms and the fatal outcome was observed at day 25 after hospitalization. Conclusions/Significance Our report adds important contributions to the clinical-epidemiological features of sporotrichosis, showing the geographic expansion of the agent within different regions of Brazil and a rare clinical manifestation (primary pulmonary sporotrichosis) caused by the emerging agent S. brasiliensis in an immunocompetent female patient. (AU)

• Processo FAPESP: 17/27265-5 - Epidemiologia molecular e perspectivas genômicas na evolução e propagação de patógenos fúngicos emergentes
• Beneficiário: Anderson Messias Rodrigues
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores