| Full text | |
| Author(s): Show less - |
Alves, Manoella do Monte
[1]
;
Milan, Eveline Pipolo
[1]
;
da Silva-Rocha, Walicyranison Plinio
[2]
;
de Sena da Costa, Alexandre Soares
[2]
;
Macielid, Bruno Araujo
[3]
;
Cavalcante Vale, Pedro Henrique
[3]
;
de Albuquerque, Paulo Roberto
[3]
;
Lima, Soraia Lopes
[4]
;
de Azevedo Melo, Analy Salles
[4]
;
Rodrigues, Anderson Messias
[5]
;
Chaves, Guilherme Maranhao
[2]
Total Authors: 11
|
| Affiliation: | [1] Univ Fed Rio Grande do Norte, Inst Med Trop, Dept Infectol, Natal, RN - Brazil
[2] Univ Fed Rio Grande do Norte, Lab Micol Med & Mol, Dept Anal Clin & Toxicol, Natal, RN - Brazil
[3] Univ Fed Rio Grande do Norte, Hosp Univ Onofre Lopes, Natal, RN - Brazil
[4] Univ Fed Sao Paulo, Disciplina Infectol, Lab Especial Micol, Sao Paulo - Brazil
[5] Univ Fed Sao Paulo, Lab Fungos Patogen Emergentes, Div Biol Celular, Dept Microbiol Imunobiol & Parasitol, Sao Paulo - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | PLoS Neglected Tropical Diseases; v. 14, n. 5 MAY 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Background A relevant case of pulmonary sporotrichosis due to Sporothrix brasiliensis is reported in a 50-year-old immunocompetent woman who had no history of skin trauma, but was in close contact with several stray cats at her nap time. The patient was hospitalized after 7 months of illness. The survey was conducted for pulmonary tuberculosis, an endemic disease in Brazil. She presented multiple central pulmonary nodules images, with central cavitation. Methodology/Principal findings The patient bronchoalveolar lavage was cultured and Sporothrix sp. growth was obtained. Then, the isolate (LMMM1097) was accurately identified to the species level by using species-specific polymerase chain reaction (PCR). Molecular diagnosis revealed that the emerging species Sporothrix brasiliensis was the agent of primary pulmonary sporotrichosis and the patient was treated with Amphotericin B lipid complex, but presented severe clinical symptoms and the fatal outcome was observed at day 25 after hospitalization. Conclusions/Significance Our report adds important contributions to the clinical-epidemiological features of sporotrichosis, showing the geographic expansion of the agent within different regions of Brazil and a rare clinical manifestation (primary pulmonary sporotrichosis) caused by the emerging agent S. brasiliensis in an immunocompetent female patient. (AU) | |
| FAPESP's process: | 17/27265-5 - Molecular epidemiology and genomic perspectives on the evolution and spread of emerging fungal pathogens |
| Grantee: | Anderson Messias Rodrigues |
| Support Opportunities: | Research Grants - Young Investigators Grants |