Study of interaction between macrophages opposite species Sporothrix brasiliensis.

• Grant number: 13/19213-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): December 01, 2013
• Effective date (End): December 31, 2017
• Field of knowledge: Biological Sciences - Microbiology
• Principal Investigator: Sandro Rogerio de Almeida
• Grantee: Luana Rossato
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 12/18598-7 - Role of pattern recognition receptors (PRRs) in the activation of macrophages in cutaneous fungal infections caused by Fonsecaea pedrosoi, Sporothrix schenckii and Trichophyton rubrum, AP.TEM
• Associated scholarship(s): 15/20290-9 - Comparative proteomic analysis between Sporothrix brasiliensis and Sporothrix schenckii, BE.EP.DR

Abstract

Sporotrichosis is presented as a subcutaneous mycosis caused by the dimorphic fungus Sporothrix sp. that affects humans and a wide variety of animals, such as dogs, cats, cattle and horses. Its habitat, soil rich in organic matter and hot and humid environments. In Brazil, the sporotrichosis in animals was considered rare, with few cases, however, in recent years the number of cases of this mycosis increased both in domestic cats and in humans, which warned of the importance of sporotrichosis in public health. In recent decades the evidence has been gaining domestic feline transmission of sporotrichosis to humans through the bite and scratch. The development of lesions at the site of inoculation of the fungus is related to the host's immune system, quantity and virulence of the agent inoculated causing skin lesions with (fixed lymphocutaneous and disseminated) and extra (articular bone, ocular, pulmonary and systemic .) Until recently, it was believed there was only one representative species of the genus Sporothrix: Sporothrix schenckii. However, recent molecular studies show that the genus Sporothrix encompasses at least six distinct species. Among them the leading cause of outbreaks proven virulence and lack of evaluation of immune response is the species Sporothrix brasiliensis. As a result, research involving host immune response, specifically, macrophages interacting with front brasiliensis, Sporothrix species, become necessary to elucidate the mechanisms and effector better understand the immune response of the host.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROSSATO, LUANA; DOS SANTOS, SUELEN SILVANA; FERREIRA, LUCAS GONCALVES; DE ALMEIDA, SANDRO ROGERIO. The impact of the absence of Toll-like receptor-2 during Sporothrix brasiliensis infection. Journal of Medical Microbiology, v. 68, n. 1, p. 87-94, JAN 2019. (13/19213-4)

ROSSATO, LUANA; DOS SANTOS, SUELEN SILVANA; FERREIRA, LUCAS GONCALVES; DE ALMEIDA, SANDRO ROGERIO. The importance of Toll-like receptor 4 during experimental Sporothrix brasiliensis infection. Medical Mycology, v. 57, n. 4, p. 489-495, JUN 2019. (13/19213-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ROSSATO, Luana. Sporothrix brasiliensis: immunological aspects and virulence.. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.