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Molecular epidemiology and genomic perspectives on the evolution and spread of emerging fungal pathogens

Grant number: 17/27265-5
Support type:Research Grants - Young Investigators Grants
Duration: October 01, 2018 - September 30, 2022
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Principal Investigator:Anderson Messias Rodrigues
Grantee:Anderson Messias Rodrigues
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Assoc. researchers:Ana Luisa Höfling-Lima ; Arnaldo Lopes Colombo ; Ferry Hagen ; Jesus Guinea ; João Nóbrega de Almeida Júnior ; Matthew Fisher ; Matthias Brock ; Roberta Peres da Silva ; Sybren de Hoog ; Zoilo Pires de Camargo
Associated grant(s):18/24304-2 - Multi-user equipament approved in grant 2017/27265-5: SeqStudio Ggnetic analyzer, AP.EMU
Associated scholarship(s):19/14799-7 - Molecular epidemiology and genomic perspectives on the evolution and spread of emerging fungal pathogens, BP.TT

Abstract

Fungal diseases kill more than 1.5 million individuals and affect more than one billion people annually around the world. These infections are still neglected by public health authorities, although most deaths are preventable. In this project, we propose to explore emerging pathogens among some of the main Brazilian mycoses, including Aspergillosis, Fusariosis, Sporotrichosis, and Paracoccidioidomycosis, integrating study systems (epidemiology, diagnosis, and genomics), expanding national and international networking. Our aims are to identify, diagnose and understand how fungal epidemics develop. The first topic of this project uses molecular epidemiology methods to investigate the pathogen-host-environment interplay, disease transmission pathways, and disease emergence. Key issues such as epidemiology, population structure, genetic diversity and host association will be extensively explored. The second topic aims to identify new genetic and proteomic markers that can be used in the early diagnosis of fungal infections using as the main strategy the detection of a marker in tissue samples and biological fluids. Diagnostic tests are essential for patient follow-up and disease control. Misdiagnosis or lack there of results in public health problems, whether due to failure to treat or inadequate therapy. The third topic employs next-generation sequencing and comparative genomics for molecular typing as well as understanding the evolution and dispersion of fungal epidemics, making it possible to track current outbreaks and epidemics in Brazil. These pieces of information provide a unique opportunity to study the biology and evolution of medically-relevant fungi. Our experimental approach is a first step towards recognizing epidemiological and evolutionary trajectories of pathogens aiming to propose better public health policies to contain fungal epidemics and therefore reduce the number of infections in animals and humans or prevent the emergence of new pathogens. (AU)

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PINHEIRO, BRENO GONCALVES; HAHN, ROSANE CHRISTINE; DE CAMARGO, ZOILO PIRES; RODRIGUES, ANDERSON MESSIAS. Molecular Tools for Detection and Identification of Paracoccidioides Species: Current Status and Future Perspectives. JOURNAL OF FUNGI, v. 6, n. 4 DEC 2020. Web of Science Citations: 1.
RODRIGUES, ANDERSON MESSIAS; KUBITSCHEK-BARREIRA, PAULA HELENA; PINHEIRO, BRENO GONCALVES; TEIXEIRA-FERREIRA, ANDRE; HAHN, ROSANE CHRISTINE; DE CAMARGO, ZOILO PIRES. Immunoproteomic Analysis Reveals Novel Candidate Antigens for the Diagnosis of Paracoccidioidomycosis Due to Paracoccidioides lutzii. JOURNAL OF FUNGI, v. 6, n. 4 DEC 2020. Web of Science Citations: 0.
DE CARVALHO, JAMILE AMBROSIO; HAGEN, FERRY; FISHER, MATTHEW C.; DE CAMARGO, ZOILO PIRES; RODRIGUES, ANDERSON MESSIAS. Genome-wide mapping using new AFLP markers to explore intraspecific variation among pathogenicSporothrixspecies. PLoS Neglected Tropical Diseases, v. 14, n. 7 JUL 2020. Web of Science Citations: 0.
MACEDO-SALES, PAMELLA ANTUNES; PEREIRA SOUZA, LUCIERI OLEGARIO; DELLA-TERRA, PAULA PORTELLA; LOZOYA-PEREZ, NANCY EDITH; DANTAS MACHADO, RICARDO LUIZ; DA SILVA DA ROCHA, ELISABETH MARTINS; LOPES-BEZERRA, LEILA MARIA; GUIMARAES, ALLAN JEFFERSON; RODRIGUES, ANDERSON MESSIAS; MANUEL MORA-MONTES, HECTOR; SOUZA DOS SANTOS, ANDRE LUIS; DE SOUZA BAPTISTA, ANDREA REGINA. Coinfection of domestic felines by distinct Sporothrix brasiliensis in the Brazilian sporotrichosis hyperendemic area. Fungal Genetics and Biology, v. 140, JUL 2020. Web of Science Citations: 0.
ALVES, MANOELLA DO MONTE; MILAN, EVELINE PIPOLO; DA SILVA-ROCHA, WALICYRANISON PLINIO; DE SENA DA COSTA, ALEXANDRE SOARES; MACIELID, BRUNO ARAUJO; CAVALCANTE VALE, PEDRO HENRIQUE; DE ALBUQUERQUE, PAULO ROBERTO; LIMA, SORAIA LOPES; DE AZEVEDO MELO, ANALY SALLES; RODRIGUES, ANDERSON MESSIAS; CHAVES, GUILHERME MARANHAO. Fatal pulmonary sporotrichosis caused by Sporothrix brasiliensis in Northeast Brazil. PLoS Neglected Tropical Diseases, v. 14, n. 5 MAY 2020. Web of Science Citations: 0.
RODRIGUES, ANDERSON MESSIAS; DELLA TERRA, PAULA PORTELLA; GREMIAO, ISABELLA DIB; PEREIRA, SANDRO ANTONIO; OROFINO-COSTA, ROSANE; DE CAMARGO, ZOILO PIRES. The threat of emerging and re-emerging pathogenic Sporothrix species. Mycopathologia, v. 185, n. 5, SI FEB 2020. Web of Science Citations: 10.
DO AMARAL, CRISTIANE CANDIDA; FERNANDES, GEISA FERREIRA; RODRIGUES, ANDERSON MESSIAS; BURGER, EVA; DE CAMARGO, ZOILO PIRES. Proteomic analysis of Paracoccidioides brasiliensis complex isolates: Correlation of the levels of differentially expressed proteins with in vivo virulence. PLoS One, v. 14, n. 7 JUL 2 2019. Web of Science Citations: 0.
HAHN, ROSANE CHRISTINE; RODRIGUES, ANDERSON MESSIAS; DELLA TERRA, PAULA PORTELLA; NERY, ANDREIA FERREIRA; HOFFMANN-SANTOS, HUGO DIAS; GOIS, HELLEN MEIRA; FERNANDES FONTES, COR JESUS; DE CAMARGO, ZOILO PIRES. Clinical and epidemiological features of paracoccidioidomycosis due to Paracoccidioides lutzii. PLoS Neglected Tropical Diseases, v. 13, n. 6 JUN 2019. Web of Science Citations: 3.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.