MOF-Based Erodible System for On-Demand Release of Bioactive Flavonoid at the Polymer-Tissue Interface

Autor(es)

Bim-Junior, Odair ^[1] ; Gaglieri, Caroline ^[2] ; Bedran-Russo, Ana K. ^[3] ; Bueno-Silva, Bruno ^[4] ; Bannach, Gilbert ^[2] ; Frem, Regina ^[5] ; Ximenes, Valdecir Farias ^[2] ; Lisboa-Filho, Paulo N. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, Dept Phys, Sch Sci, UNESP, BR-17033360 Bauru, SP - Brazil

^[2] Sao Paulo State Univ, UNESP, Dept Chem, Sch Sci, BR-17033360 Bauru, SP - Brazil

^[3] Univ Illinois Chicago UIC, Dept Restorat Dent, Coll Dent, Chicago, IL 60612 - USA

^[4] Guarulhos Univ UNG, Dent Res Div, BR-07023080 Guarulhos - Brazil

^[5] Sao Paulo State Univ, Inst Chem, Dept Inorgan Chem, UNESP, BR-14800060 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ACS BIOMATERIALS SCIENCE & ENGINEERING; v. 6, n. 8, p. 4539-4550, AUG 2020.
• Citações Web of Science: 0

Resumo

Plant-derived compounds incite applications virtually on every biomedical field due to the expedient antioxidant, anti-inflammatory and antimicrobial properties in conjunction with a natural character. Here, quercetin (QCT), a flavonoid with therapeutic potentials relevant to the oral environment, was encapsulated within metal-organic frameworks (MOFs) to address the concept of on-demand release of phytochemicals at the biointerface. We verified the applicability of a microporous MOF (ZIF8) as a controlled-release system for QCT, as well as investigated the incorporation of QCT@ZIF-8 microparticles into a dental adhesive resin for desirable therapeutic capabilities at the tooth-restoration interface. QCT was encapsulated within the frameworks through a water-based, one-step synthetic process. The resulting QCT@ZIF-8 microparticles were characterized with respect to chemical composition, crystal structure, thermal behavior, micromorphology, and release profile under acidic and physiological conditions. A model dental adhesive formulation was enriched with the bioactive microparticles; both the degree of conversion (DC) of methacrylic double bonds and the polymer thermal behavior were accounted for. The results confirm that crystalline QCT@ZIF-8 microparticles with attractive loading capacities, submicron sizes, high thermal stability and responsiveness to environmental pH change were successfully manufactured. The concentration of QCT@ZIF-8 in the resin system was a key factor to maintain an optimal DC plateau and rate of polymerization. Essentially, one-step encapsulation of QCT in biocompatible ZIF-8 matrices can be easily achieved, and QCT@ZIF-8 microparticles proved as smart platforms to carry bioactive compounds with potential use to prevent microbial and enzymatic degradation of hard tissues and extracellular matrix components. (AU)

• Processo FAPESP: 17/08820-8 - Síntese e caracterização de biopolímeros a partir de óleos vegetais e glicerol seguindo os princípios da química verde.
• Beneficiário: Gilbert Bannach
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50926-0 - INCT 2014: biodiversidade e produtos naturais
• Beneficiário: Vanderlan da Silva Bolzani
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático
• Processo FAPESP: 18/02186-8 - Uso de MOFs (metal-organic frameworks) automontáveis na prevenção da degradação da matriz dentinária: cápsulas cristalinas para proteases e revestimentos protetores para fibrilas de colágeno
• Beneficiário: Odair Bim Júnior
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado