MOF-Based Erodible System for On-Demand Release of Bioactive Flavonoid at the Polymer-Tissue Interface

Author(s)

Bim-Junior, Odair ^[1] ; Gaglieri, Caroline ^[2] ; Bedran-Russo, Ana K. ^[3] ; Bueno-Silva, Bruno ^[4] ; Bannach, Gilbert ^[2] ; Frem, Regina ^[5] ; Ximenes, Valdecir Farias ^[2] ; Lisboa-Filho, Paulo N. ^[1]

Affiliation

^[1] Sao Paulo State Univ, Dept Phys, Sch Sci, UNESP, BR-17033360 Bauru, SP - Brazil

^[2] Sao Paulo State Univ, UNESP, Dept Chem, Sch Sci, BR-17033360 Bauru, SP - Brazil

^[3] Univ Illinois Chicago UIC, Dept Restorat Dent, Coll Dent, Chicago, IL 60612 - USA

^[4] Guarulhos Univ UNG, Dent Res Div, BR-07023080 Guarulhos - Brazil

^[5] Sao Paulo State Univ, Inst Chem, Dept Inorgan Chem, UNESP, BR-14800060 Araraquara, SP - Brazil

• Document type: Journal article
• Source: ACS BIOMATERIALS SCIENCE & ENGINEERING; v. 6, n. 8, p. 4539-4550, AUG 2020.
• Web of Science Citations: 0

Abstract

Plant-derived compounds incite applications virtually on every biomedical field due to the expedient antioxidant, anti-inflammatory and antimicrobial properties in conjunction with a natural character. Here, quercetin (QCT), a flavonoid with therapeutic potentials relevant to the oral environment, was encapsulated within metal-organic frameworks (MOFs) to address the concept of on-demand release of phytochemicals at the biointerface. We verified the applicability of a microporous MOF (ZIF8) as a controlled-release system for QCT, as well as investigated the incorporation of QCT@ZIF-8 microparticles into a dental adhesive resin for desirable therapeutic capabilities at the tooth-restoration interface. QCT was encapsulated within the frameworks through a water-based, one-step synthetic process. The resulting QCT@ZIF-8 microparticles were characterized with respect to chemical composition, crystal structure, thermal behavior, micromorphology, and release profile under acidic and physiological conditions. A model dental adhesive formulation was enriched with the bioactive microparticles; both the degree of conversion (DC) of methacrylic double bonds and the polymer thermal behavior were accounted for. The results confirm that crystalline QCT@ZIF-8 microparticles with attractive loading capacities, submicron sizes, high thermal stability and responsiveness to environmental pH change were successfully manufactured. The concentration of QCT@ZIF-8 in the resin system was a key factor to maintain an optimal DC plateau and rate of polymerization. Essentially, one-step encapsulation of QCT in biocompatible ZIF-8 matrices can be easily achieved, and QCT@ZIF-8 microparticles proved as smart platforms to carry bioactive compounds with potential use to prevent microbial and enzymatic degradation of hard tissues and extracellular matrix components. (AU)

• FAPESP's process: 17/08820-8 - Synthesis and characterization of biopolymers from vegetable oils and glycerol following the principles of green chemistry
• Grantee: Gilbert Bannach
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/50926-0 - INCT 2014: biodiversity and natural products
• Grantee: Vanderlan da Silva Bolzani
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
• FAPESP's process: 18/02186-8 - Use of self-assembled metal-organic frameworks (MOFs) in preventing degradation of dentin matrix: crystalline shells for proteases and protective coatings for collagen fibrils
• Grantee: Odair Bim Júnior
• Support Opportunities: Scholarships in Brazil - Post-Doctoral