Development of natural polymeric microcapsules for antimicrobial drug delivery: triclosan loaded chitosan and alginate-based microcapsules

Autor(es)

Alves de Lima, Caroline Santos ^[1] ; Costa Varca, Gustavo Henrique ^[2] ; da Costa, Sirlene Maria ^[1] ; Ferraz, Humberto Gomes ^[3] ; da Silva Santos, Ana Carolina ^[4] ; Lopes, Patricia Santos ^[5] ; da Costa, Silgia Aparecida ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo - Brazil

^[2] IPEN CNEN SP, Nucl & Energy Res Inst, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Sao Paulo - Brazil

^[4] State Univ Sao Paulo, Dept Microbiol & Immunol, Botucatu, SP - Brazil

^[5] Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Diadema - Brazil

• Tipo de documento: Artigo Científico
• Fonte: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY; v. 46, n. 9 AUG 2020.
• Citações Web of Science: 0

Resumo

The goal of this work was the development of natural polymeric microcapsules for antimicrobial drug delivery - triclosan loaded alginate and chitosan-based microcapsules for potential coating applications in substrates such as textiles or plastics. Microcapsules containing 2.5% (w/w) or 3% (w/w) triclosan in both core and matrix were synthesized and evaluated by Fourier-transform infrared spectroscopy, scanning electron microscopy, confocal microscopy, differential scanning calorimetry, thermogravimetry, and antimicrobial activity. The microcapsules produced featured spherical and mostly irregularly-shaped surfaces composed by an alginate core in a chitosan outer matrix, as revealed by confocal microscopy, and antimicrobial activity againstS. aureusandE. coliwith inhibition halos up to 60 mm and 25 mm respectively, granted by a triclosan loading of 61.66%. The thermal analysis suggested that the polymers protected the active substance from temperature-induced degradation. In conclusion, these microcapsules may be applied toward antimicrobial functionalization of plastics, textiles and other materials. (AU)

• Processo FAPESP: 15/08845-5 - Estudo do desenvolvimento de microcápsulas de polímeros naturais para aplicação em têxteis médicos
• Beneficiário: Caroline Santos Alves de Lima
• Modalidade de apoio: Bolsas no Brasil - Mestrado