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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development of natural polymeric microcapsules for antimicrobial drug delivery: triclosan loaded chitosan and alginate-based microcapsules

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Author(s):
Alves de Lima, Caroline Santos [1] ; Costa Varca, Gustavo Henrique [2] ; da Costa, Sirlene Maria [1] ; Ferraz, Humberto Gomes [3] ; da Silva Santos, Ana Carolina [4] ; Lopes, Patricia Santos [5] ; da Costa, Silgia Aparecida [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo - Brazil
[2] IPEN CNEN SP, Nucl & Energy Res Inst, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Sao Paulo - Brazil
[4] State Univ Sao Paulo, Dept Microbiol & Immunol, Botucatu, SP - Brazil
[5] Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Diadema - Brazil
Total Affiliations: 5
Document type: Journal article
Source: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY; v. 46, n. 9 AUG 2020.
Web of Science Citations: 0
Abstract

The goal of this work was the development of natural polymeric microcapsules for antimicrobial drug delivery - triclosan loaded alginate and chitosan-based microcapsules for potential coating applications in substrates such as textiles or plastics. Microcapsules containing 2.5% (w/w) or 3% (w/w) triclosan in both core and matrix were synthesized and evaluated by Fourier-transform infrared spectroscopy, scanning electron microscopy, confocal microscopy, differential scanning calorimetry, thermogravimetry, and antimicrobial activity. The microcapsules produced featured spherical and mostly irregularly-shaped surfaces composed by an alginate core in a chitosan outer matrix, as revealed by confocal microscopy, and antimicrobial activity againstS. aureusandE. coliwith inhibition halos up to 60 mm and 25 mm respectively, granted by a triclosan loading of 61.66%. The thermal analysis suggested that the polymers protected the active substance from temperature-induced degradation. In conclusion, these microcapsules may be applied toward antimicrobial functionalization of plastics, textiles and other materials. (AU)

FAPESP's process: 15/08845-5 - STUDY OF NATURAL POLYMER MICROCAPSULES DEVELOPMENT FOR APPLICATION IN MEDICAL TEXTILES
Grantee:Caroline Santos Alves de Lima
Support Opportunities: Scholarships in Brazil - Master