| Texto completo | |
| Autor(es): |
Schmidt, Mariana Costa Braga
[1, 2]
;
Morais, Katia L. P.
[1, 2, 3]
;
de Almeida, Maira Estanislau Soares
[2, 3]
;
Iqbal, Asif
[2, 3]
;
Goldfeder, Mauricio Barbugiani
[2, 3]
;
Chudzinski-Tavassi, Ana Marisa
[1, 2]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo, Dept Biochem, Sao Paulo, SP - Brazil
[2] Butantan Inst, Lab Mol Biol, Ave Vital Brasil 1500, BR-05503900 Sao Paulo, SP - Brazil
[3] Butantan Inst, Ctr Excellence New Target Discovery, Sao Paulo, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CELL ADHESION & MIGRATION; v. 14, n. 1, p. 129-138, JAN 1 2020. |
| Citações Web of Science: | 6 |
| Resumo | |
In a tumor microenvironment, endothelial cell migration and angiogenesis allow cancer to spread to other organs causing metastasis. Indeed, a number of molecules that are involved in cytoskeleton re-organization and intracellular signaling have been investigated for their effects on tumor cell growth and metastasis. Alongside that, Amblyomin-X, a recombinant Kunitz-type protein, has been shown to reduce metastasis and tumor growth in in vivo experiments. In the present report, we provide a mechanistic insight to these antitumor effects, this is, Amblyomin-X modulates Rho-GTPases and uPAR signaling, and reduces the release of MMPs, leading to disruption of the actin cytoskeleton and decreased cell migration of tumor cell lines. Altogether, our data support a role for Amblyomin-X as a novel potential antitumor drug. (AU) | |
| Processo FAPESP: | 13/07467-1 - CeTICS - Centro de Toxinas, Imuno-Resposta e Sinalização Celular |
| Beneficiário: | Hugo Aguirre Armelin |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 15/50040-4 - Rational approach for searching molecular targets involved in inflammatory events and cell survival |
| Beneficiário: | Ana Marisa Chudzinski-Tavassi |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Centros de Pesquisa Aplicada |
| Processo FAPESP: | 14/24512-3 - Avaliação do efeito do Amblyomin-X na ativação de células endoteliais pelo microambiente tumoral |
| Beneficiário: | Mariana Costa Braga Schmidt |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |