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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Amblyomin-X, a recombinant Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells

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Author(s):
Schmidt, Mariana Costa Braga [1, 2] ; Morais, Katia L. P. [1, 2, 3] ; de Almeida, Maira Estanislau Soares [2, 3] ; Iqbal, Asif [2, 3] ; Goldfeder, Mauricio Barbugiani [2, 3] ; Chudzinski-Tavassi, Ana Marisa [1, 2]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Dept Biochem, Sao Paulo, SP - Brazil
[2] Butantan Inst, Lab Mol Biol, Ave Vital Brasil 1500, BR-05503900 Sao Paulo, SP - Brazil
[3] Butantan Inst, Ctr Excellence New Target Discovery, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: CELL ADHESION & MIGRATION; v. 14, n. 1, p. 129-138, JAN 1 2020.
Web of Science Citations: 6
Abstract

In a tumor microenvironment, endothelial cell migration and angiogenesis allow cancer to spread to other organs causing metastasis. Indeed, a number of molecules that are involved in cytoskeleton re-organization and intracellular signaling have been investigated for their effects on tumor cell growth and metastasis. Alongside that, Amblyomin-X, a recombinant Kunitz-type protein, has been shown to reduce metastasis and tumor growth in in vivo experiments. In the present report, we provide a mechanistic insight to these antitumor effects, this is, Amblyomin-X modulates Rho-GTPases and uPAR signaling, and reduces the release of MMPs, leading to disruption of the actin cytoskeleton and decreased cell migration of tumor cell lines. Altogether, our data support a role for Amblyomin-X as a novel potential antitumor drug. (AU)

FAPESP's process: 13/07467-1 - CeTICS - Center of Toxins, Immune-Response and Cell Signaling
Grantee:Hugo Aguirre Armelin
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 14/24512-3 - Evaluation of Ambiyomin-X effect in activation of endothelial cells by tumor microenvironment
Grantee:Mariana Costa Braga Schmidt
Support type: Scholarships in Brazil - Master
FAPESP's process: 15/50040-4 - Rational approach for searching molecular targets involved in inflammatory events and cell survival
Grantee:Ana Marisa Chudzinski-Tavassi
Support type: Research Grants - Research Centers in Engineering Program