Fluoxetine chronic exposure affects growth, behavior and tissue structure of zebrafish

Autor(es)

de Farias, Natalia Oliveira ^{[1, 2, 3]} ; Oliveira, Rhaul ^[2] ; Silva Moretti, Patricia Natalia ^[1] ; Pinto, Joana Mona e ^[1] ; Oliveira, Ana Clara ^[1] ; Santos, Viviani Lara ^[1] ; Rocha, Paula Suares ^[2] ; Andrade, Thayres Sousa ^[4] ; Grisolia, Cesar Koppe ^[1]

Afiliação do(s) autor(es)

^[1] Univ Brasilia, Inst Biol, Dept Genet & Morfol, Lab Genet Toxicol, BR-70910900 Brasilia, DF - Brazil

^[2] Univ Estadual Campinas, UNICAMP, Fac Tecnol, BR-13484332 Limeira, SP - Brazil

^[3] Univ Estadual Campinas, Inst Biol, IB UNICAMP, Programa Posgrad Biol Anim, BR-13083862 Campinas, SP - Brazil

^[4] Univ Fed Ceara, Campus Crateus, BR-63700000 Crateus, Ceara - Brazil

• Tipo de documento: Artigo Científico
• Fonte: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY; v. 237, NOV 2020.
• Citações Web of Science: 0

Resumo

Fluoxetine (FLX) is among the top 100 pharmaceutical prescribed annually worldwide and consequently is often detected in wastewater treatment plant effluent and surface waters, in concentrations up to 2.7 and 0.33 mu g/L, respectively. Despite the presence of FLX in surface waters, little is known about its chronic effects in fish. Thus, this study aimed at investigating the chronic toxicity of FLX to Danio rerio adults. Rate of weight gain, behavior (feeding and swimming activity) and tissue organization (liver and intestine) were evaluated, after 30 days exposure. A lower rate of weight gain was observed at 100 mu g/L FLX. The food intake time decreased, showing a decrease in fish appetite. The preference for the upper aquarium layer was observed at 10 and 100 mu g/L of FLX, indicating an inhibition of the stress level (anxiolytic effect). Mild to moderate damage of hepatic tissue and a decrease epithelium height and increase in villus height of intestine were observed in fish exposed to concentrations as low as 0.01 mu g/L. Based on obtained results, chronic exposure of fish to FLX could affect swimming and feeding behavior and alter morphological structure of liver and intestine tissues at environmental levels. (AU)

• Processo FAPESP: 18/03108-0 - O papel do teste com embrião de Peixe-Zebra na avaliação integrada da qualidade da água em áreas de plantio de cana-de-açúcar
• Beneficiário: Rhaul de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado